桑枝颗粒对糖尿病大鼠的作用研究

目的：研究桑枝颗粒对糖尿病大鼠糖脂代谢的影响。方法：采用四氧嘧啶复制糖尿病大鼠模型,灌胃给药4周后测定空腹血糖（FPG）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-c）、低密度脂蛋白胆固醇（LDL-c）、游离脂肪酸（FFA）。结果糖尿病模型大鼠的FPG、TG、TC、LDL-c、FFA含量显著高于正常对照组大鼠,HDL-c含量明显低于正常大鼠,差异具有显著性（P〈0.05）;桑枝颗粒治疗组FPG、TG、TC、LDL-c、FFA显著降低,HDL-c显著升高,与对照组比较,差异具有显著性（P〈0.01）。结论桑枝颗粒可降低糖尿病大鼠的血糖及改善血脂紊乱。

A Reasearch on the Applications of Mori Granules in Treating Diabetic Rats

Objective： To study the effects of mori granules on glucose and lipid metabolism of diabetic rats. Methods：Copy diabetic rat model using alloxan, give medicine by intragastric administration for 4 weeks and then measure the fasting plasma glucose （FPG）, triglyceride （TG）, total cholesterol （TC）, high density lipoprotein cholesterol （HDL-c）, low-density lipoprotein cholesterol （LDL-c） and free fatty acid （FFA）. Results：FPG, TG, TC, LDL-c, FFA in diabetic rats are significantly higher than that in normal control group, HDL-c are significantly lower than that in normal rats. The difference is significant （P〈0.05）. In mori granules treatment group, FPG, TG, TC, LDL-c, FFA significantly reduce, HDL-c significantly increase. Compared with the control group, the difference is significant （P〈0.01）. Conclusion：Mori particles can reduce the blood glucose of diabetic rats and improve their dyslipidemia.