| 盐酸小檗碱脂质体制备与质量评价研究 |
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| 引用本文： | 李莉,王振华,王玉蓉,周洪伟.盐酸小檗碱脂质体制备与质量评价研究[J].辽宁中医学院学报,2011(7):221-223. |
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| 作者姓名： | 李莉 王振华 王玉蓉 周洪伟 |
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| 作者单位： | [1]辽宁中医药大学,辽宁大连116600 [2]北京中医药大学,北京100102 |
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| 摘 要： | 目的：制备盐酸小檗碱脂质体，并对其质量进行评价。方法：采用薄膜分散-pH梯度-探头超声法制备盐酸小檗碱脂质体，测定其包封率和粒径，以透射电镜观察脂质体形态。结果：盐酸小檗碱脂质体平均粒径为（158±5）nm；盐酸小檗碱包封率为91．8％。结论：结果表明脂质体粒径均一，体系稳定。
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| 关 键 词： | 盐酸小檗碱 脂质体 包封率 |
Preparation and Quality Evaluation of Berberine Hydrochloride Liposomes |
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| LI Li,WANG Zhen-hua,WANG Yu-rong,ZHOU Hong-wei.Preparation and Quality Evaluation of Berberine Hydrochloride Liposomes[J].Journal of Liaoning College of Traditional Chinese Medicine,2011(7):221-223. |
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| Authors: | LI Li WANG Zhen-hua WANG Yu-rong ZHOU Hong-wei |
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| Institution: | 1. Liaoning University of Traditional Chinese Medicine, Dalian 116600, Liaoning, China; 2. Beijing University of Chinese Medicine, Beijing 100102, China ) |
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| Abstract: | Objective ： To prepare and evaluate the quality of berberine hydrochloride liposomes. Methods ： Berberine hydrochloride liposome were prepared by film hydration- pH gradient- probe ultrasonic- method and its morphology was examined by the transmission electron microscope. The shape of liposomes, particles size, entrapment efficacy were evaluated. Results ： The average diameter of berberine liposomes were （ 158±5 ） nm.The encapsulation efficiency of berberine liposome was 91.8%. Conclusion ： The results showed that the liposomes have uniform size and encapsulation efficiency is well. |
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| Keywords: | berberine liposomes entrapment efficiency |
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