不同类型冠心病患者C反应蛋白与氧化型低密度脂蛋白自身抗体水平的比较

目的 研究C反应蛋白(CRP)、氧化型低密度脂蛋白自身抗体(anti-oxLDL)与急性冠状动脉综合征(ACS)的关系.方法 分别测定26例急性心肌梗死、29例不稳定性心绞痛、20例稳定性心绞痛和21例对照者的CRP、anti-oxLDL和anti-LDL水平,比较各组中上述指标有无显著差异并评估CRP水平与anti-oxLDL水平的相关性.结果 ACS患者(包括急性心肌梗死组和不稳定性心绞痛组)的CRP水平明显高于稳定性心绞痛组和对照组(P＜0.05);ACS患者的anti-oxLDL水平明显高于稳定性心绞痛组和对照组(P＜0.05);各组anti-oxLDL水平比较无显著差异(P＞0.05);各组中CRP水平与anti-oxLDL水平成显著正相关(P＜0.001).结论 特异性抗原oxLDL的免疫反应,在导致斑块的不稳定及ACS的发生中可能起着重要作用,anti-oxLDL水平可能是评价ACS斑块不稳定的重要特异性标志.

Levels of C-reactive protein and antibodies against oxidized low-density lipoprotein in patients with different types of coronary heart disease

Objective To investigate the relation of the levels of C-reactive protein(CRP) and antibodies against oxidized low-density lipoprotein(anti-oxLDL) to with acute coronary syndrome(ACS).Methods The levels of CRP,anti-oxLDL and anti-LDL were measured and compared in 96 subjects including 26 with acute myocardial infarction(AMI),29 with unstable angina pectoris(UAP),20 with stable angina pectoris(SAP) and 21 control subjects to evaluate the relationship between CRP and anti-oxLDL.Results Both CRP and anti-oxLDL levels in patients with ACS,including AMI and UAP,were significantly higher than those in SAP patients and the control subjects(P<0.05),but the level of anti-LDL showed no significant difference between the groups(P>0.05).There was significant positive correlation between the levels of CRP and anti-oxLDL(P<0.001).Conclusion The specific immune response to oxLDL may play an important role in the instability of plaque and the occurrence of ACS,and anti-oxLDL level may serve as an important specific marker for the instability of plaque.