早期鼻咽癌血管内皮细胞生长因子表达与肿瘤组织18F-FDG摄取的关系

目的 研究早期鼻咽癌组织血管内皮细胞生长因子(VEGF)表达及肿瘤组织~(18)F-FDG摄取的情况,并探讨早期鼻咽癌组织VEGF表达与~(18)F-FDG摄取的关系.方法 对40例I,II期鼻咽癌患者进行正电子发射体层显像检查,测定鼻咽原发灶肿瘤组织的~(18)F-FDG最大摄取值和标准摄取值(SUV_(max)和SUV_(mean)),应用标准链霉菌抗生物素蛋白-过氧化物酶亲和免疫组化法检测40例患者肿瘤组织VEGF的表达.结果 40例早期鼻咽癌组织的SUV_(max)>与SUV_(mean)分别为9.45±1.87和6.04±1.09,T_1期肿瘤原发灶SUV_(max)与SUV_(mean)分别为8.95±1.91和5.61±1.08,T_2期的原发灶SUV_(max)与SUV_(mean)分别为11.55±1.70和7.98±1.1,T_2期原发灶SUV_(max)和SUV_(mean)高于T_1期(t=4.46,P<0.001;t=6.763,P<0.001).非角化分化型肿瘤原发灶SUV_(max)与SUV_(mean)分别为9.74±1.82和6.82±1.23,非角化未分化型肿瘤原发灶SUV_(max)与SUV_(mean)分别为10.44±2.16和6.68±1.35,非角化分化型和非角化未分化型肿瘤原发灶SUV_(max)和SUV_(mean)无差别(t=1.230,P>0.05;t=0.346,P>0.05).40例鼻明癌组织VEGF染色阳性细胞率为60.8%;鼻咽癌组织FDG摄取(SUV_(max))和VEGF表达的细胞阳性率相关(r=0.460,P=0.03).结论 早期鼻咽癌组织FDG摄取与肿瘤组织VEGF过度表达相关,其SUV值反映了鼻咽癌组织的葡萄糖代谢情况,同时也在一定程度上反映了肿瘤组织乏氧的程度.

Abstract：

Objective To study the overexpression of vascular endothelial growth factor (VEGF) and fluorine-18 fluorodeoxyglucose (FDG) uptake in early-stage nasopharyngeal carcinoma (NPC) and evaluate their relationship. Methods FDG positron emission tomography (PET) was performed in forty patients with stage I and stage II NPC. The maximum and mean standard uptake values (SUV_(max) and SUV_(mean) ,respectively) were measured in each patient, and the expression of VEGF was measured on paraffin sections using immunohistochemistry. Results The FDG uptake in the patients were 9.45±1.87 (SUV_(max)) and 6.04±1.09 (SUV_(mean)), 8.95±1.91 (SUV_(max)) and 6.04±1.09 (SUV_(mean)) in stage I patients, and 11.55±1.70 (SUV_(max)) and 7.98±1.1 (SUV_(mean)) in stage II patients. The FDG uptake of stage II patients was higher than that of stage I patients. The FDG uptake of non-keratinizing differentiated carcinoma was 9.74±1.82 (SUV_(max)) and 6.82±1.23 (SUV_(mean)) and 10.44±2.16 (SUV_(max)) and 6.68±1.35 (SUV_(mean)) in non-keratinizing undifferentiated carcinoma, showing no significant differences between them (SUV_(max): t=1.230, P>0.05; SUV_(mean): t=0.346, P>0.05). The VEGF-positive cells were 60.80% in the tumor. A correlation between VEGF expression and FDG uptake in he tumor was noted (r=0.460, P=0.03). Conclusion VEGF overexpression is correlated to FDG uptake in patients with early-stage NPC. The SUV value reflects the glucose metabolism of NPC, and also shows the degree of oxygen insufficiency in the tumor tissue.

Relationship between fluorodeoxyglucose uptake and vascular endothelial growth factor in early-stage nasophygeal carcinoma

Objective To study the overexpression of vascular endothelial growth factor (VEGF) and fluorine-18 fluorodeoxyglucose (FDG) uptake in early-stage nasopharyngeal carcinoma (NPC) and evaluate their relationship. Methods FDG positron emission tomography (PET) was performed in forty patients with stage I and stage II NPC. The maximum and mean standard uptake values (SUV_(max) and SUV_(mean) ,respectively) were measured in each patient, and the expression of VEGF was measured on paraffin sections using immunohistochemistry. Results The FDG uptake in the patients were 9.45±1.87 (SUV_(max)) and 6.04±1.09 (SUV_(mean)), 8.95±1.91 (SUV_(max)) and 6.04±1.09 (SUV_(mean)) in stage I patients, and 11.55±1.70 (SUV_(max)) and 7.98±1.1 (SUV_(mean)) in stage II patients. The FDG uptake of stage II patients was higher than that of stage I patients. The FDG uptake of non-keratinizing differentiated carcinoma was 9.74±1.82 (SUV_(max)) and 6.82±1.23 (SUV_(mean)) and 10.44±2.16 (SUV_(max)) and 6.68±1.35 (SUV_(mean)) in non-keratinizing undifferentiated carcinoma, showing no significant differences between them (SUV_(max): t=1.230, P>0.05; SUV_(mean): t=0.346, P>0.05). The VEGF-positive cells were 60.80% in the tumor. A correlation between VEGF expression and FDG uptake in he tumor was noted (r=0.460, P=0.03). Conclusion VEGF overexpression is correlated to FDG uptake in patients with early-stage NPC. The SUV value reflects the glucose metabolism of NPC, and also shows the degree of oxygen insufficiency in the tumor tissue.