| 荧光原位杂交技术在膀胱癌诊断中的应用价值 |
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| 引用本文： | 单正飞,郑少斌,吴芃,谭万龙,左翼,周海宽,齐桓,张鹏,彭红梅.荧光原位杂交技术在膀胱癌诊断中的应用价值[J].南方医科大学学报,2010,30(7). |
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| 作者姓名： | 单正飞 郑少斌 吴芃 谭万龙 左翼 周海宽 齐桓 张鹏 彭红梅 |
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| 作者单位： | 南方医科大学南方医院泌尿外科,广东广州,510515 |
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| 摘 要： | 目的 探讨荧光原位杂交技术(FISH)在膀胱癌诊断中的价值,并与常规的尿脱落细胞学对比.方法 收集100例疑似尿路移行上皮细胞肿瘤的血尿患者在行膀胱镜检查之前的尿液标本,分别做尿细胞学检测和荧光原位杂交分析.20例正常人尿液标本,用于建立FISH阈值,作为阳性判断的标准.结果 细胞学和FISH的总体灵敏度分别为43.2%、82.4%,特异度分别为:92.3%、88.5%,诊断符合率分别为:56.0%、84.0%,细胞学和FISH在灵敏度、诊断符合率、非浸润性肿瘤和初发肿瘤等方面的差异均有统计学意义.结论 在膀胱癌诊断中FISH较常规细胞学具有较高的灵敏度和诊断符合率,更易检出早期肿瘤.
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| 关 键 词： | 荧光原位杂交 膀胱肿瘤 细胞学 |
Predictive value of fluorescence in situ hybridization in patients with bladder cancer |
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| SHAN Zheng-fei,ZHENG Shao-bin,WU Peng,TAN Wan-long,ZUO Yi,ZHOU Hai-kuan,QI Huan,ZHANG Peng,PENG Hong-mei.Predictive value of fluorescence in situ hybridization in patients with bladder cancer[J].Journal of Southern Medical University,2010,30(7). |
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| Authors: | SHAN Zheng-fei ZHENG Shao-bin WU Peng TAN Wan-long ZUO Yi ZHOU Hai-kuan QI Huan ZHANG Peng PENG Hong-mei |
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| Institution: | SHAN Zheng-fei,ZHENG Shao-bin,WU Peng,TAN Wan-long,ZUO Yi,ZHOU Hai-kuan,QI Huan,ZHANG Peng,PENG Hong-mei Department of Urology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China |
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| Abstract: | Objective To assess the value of fluorescence in situ hybridization (FISH) in the diagnosis of bladder cancer. Methods Urine samples from 100 patients suspected of having bladder cancer were collected before cystoscopy for immediate urine cytology and FISH analysis. The criteria for FISH abnormality were determined by evaluating the urine specimens from 20 subjects without urogenital neoplasm. Results The overall sensitivity of cytology and FISH was 43.2% and 82.4%, and their specificity was 92.3% and 88.5%... |
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| Keywords: | fluorescence in situ hybridization bladder cancer cytology |
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