激素性股骨头坏死股骨头微血管的变化

目的 通过观察激素性股骨头坏死股骨头微血管的变化，探讨股骨头缺血性坏死的机制。方法 将20只健康新西兰兔随机分成两组，每组10只。A组：模型组，注射马血清及醋酸泼尼松龙造模；B组：正常对照组，采用墨汁灌注及病理组织切片对股骨头的微循环结构及组织细胞的病理变化进行观察。结果 墨汁灌注结果显示：模型组股骨头血管显著减少，灌注不全面，血管出现明显栓塞。病理组织切片HE染色显示：骨细胞核固缩，部分血管栓塞，骨髓腔内造血组织明显减少。结论 大剂量激素引起的微血管内皮损伤，血管栓塞，可能是造成股骨头坏死的重要原因。

Pathological changes of the blood vessels in rabbit femoral head with glucocorticoid-induced necrosis

Objective To observe the pathological changes in the blood vessels in rabbit femoral head with glucocorticoid-induced necrosis and investigate the pathogenesis of glucocorticoid-induced osteonecrosis. Methods Twenty New Zealand white rabbits were randomly divided into two groups, namely group A. which was injected with horse serum and prednisone and group B as the control group. Chinese ink was injected into the femoral cavity of the rabbits to observe the blood vessels in the femoral head under optical microscope and the femoral head was examined histopathologically. Results Compared with the normal control group, the rabbits in group A had significantly decreased number ofperfused vessels, which was featured by defective perfusion, osteocytie pyknosis or necrosis, increase of empty ostoocyte lacunae and fat cells, decrease of hematopoietic tissue, and blood vessel occlusion. Conclusion Vascular occlusion and vasculitis due to glucocorticoid treatment may cause avascular necrosis of the femoral head.