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链脲佐菌素糖尿病模型动物血糖及体征动态变化的研究
引用本文:余传林,朱正光,雷林生,陈娜娜,吴曙光.链脲佐菌素糖尿病模型动物血糖及体征动态变化的研究[J].南方医科大学学报,2008,28(1):132-133.
作者姓名:余传林  朱正光  雷林生  陈娜娜  吴曙光
作者单位:南方医科大学药学院药物研究所,广东,广州,510515
摘    要:目的 探讨链脲佐菌素(streptozotocin)糖尿病模型动物血糖和体征动态变化的特点.方法 链脲佐菌素1次或多次腹腔注射,分别建立大鼠和小鼠糖尿病模型;检测血糖变化,以进食量(g)/体质量(g),饮水量(ml)/体质量(g)计算进食量系数和饮水量系数.结果 雄性大鼠链脲佐菌素60 mg/kg糖尿病成模率为65.0%,血糖在注射后15 d达到高峰,15~25 d保持在较高水平,25d后出现明显的下降.小鼠链脲佐菌素200 mg/kg分5次建立糖尿病成模率为90.0%,血糖的动态变化与大鼠类似,但血糖下降不明显.在这两个糖尿病模型中,动物的饮水量系数变化与血糖水平变化的相关性最高,相关系数r>0.97.结论 链脲佐菌素糖尿病模型动物的血糖水平在造模开始后的15~25 d维持在较高水平,可作为观察降血糖药物疗效的适宜时段.饮水量系数是反映血糖的水平变化的适宜指标.

关 键 词:链脲佐菌素  糖尿病  动物模型  链脲佐菌素  糖尿病模型  动物  降血糖  态变化  研究  animal  models  body  blood  sugar  dynamic  changes  指标  适宜时段  药物疗效  造模  血糖水平  相关系数  相关性  水平变化  血糖下降  鼠类
文章编号:1673-4254(2008)01-0132-02
收稿时间:2007-03-08
修稿时间:2007年3月8日

Study of dynamic changes of blood sugar and body signs in streptozotocin-induced diabetic animal models
YU Chuan-lin,ZHU Zheng-guang,LEI Lin-sheng,CHEN Na-na,WU Shu-guang.Study of dynamic changes of blood sugar and body signs in streptozotocin-induced diabetic animal models[J].Journal of Southern Medical University,2008,28(1):132-133.
Authors:YU Chuan-lin  ZHU Zheng-guang  LEI Lin-sheng  CHEN Na-na  WU Shu-guang
Institution:Pharmaceutical Institute of Pharmaceutical School, Southern Medical University, Guangzhou 510515, China.
Abstract:OBJECTIVE: To explore the dynamic changes of blood sugar and body's signs in streptozotocin diabetic animal models. METHODS: Rat and mouse diabetic models were established by a single intraperitoneal (ip) injection and 5-day successive ip injections of streptozotocin respectively. Blood sugar levels were measured. The food consumption index (consumption of food/body weight) and the water consumption index (consumption of water/body weight) were calculated. RESULTS: Sixty five point zero percent male rats received streptozotocin, 60 mg/kg ip, developed diabetes mellitus. The blood sugar remained in high level between the 15th day and the 25th day after injection, and it began to decline afterwards. By 5-day ip injections of streptozotocin, 40 mg/kg daily, 90.0% male mice developed diabetes mellitus. Dynamic changes of blood sugar of diabetic mouse were similar to those of rats, except that the blood sugar of mice did not decline as obvious as that of rats. The changes of water consumption index were in best fit with the changes of blood sugar in both models, with correlation index r>0.970. CONCLUSION: The blood sugar of diabetic animal model stayed in high level from the 15th day to the 25th day after the beginning of injection. And the period is suitable for observing effect of anti-diabetic drugs. The water consumption index can reflect the blood sugar levels of diabetes animals.
Keywords:streptozotocin  diabetes mellitus  animal models
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