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乙酰肝素酶和核转录因子κB在胰腺癌中的表达及其临床意义
引用本文:吴武军,潘承恩,刘青光,孟珂伟,余海波,王幼黎,赵琳.乙酰肝素酶和核转录因子κB在胰腺癌中的表达及其临床意义[J].南方医科大学学报,2007,27(8):1267-1270.
作者姓名:吴武军  潘承恩  刘青光  孟珂伟  余海波  王幼黎  赵琳
作者单位:1. 西安交通大学第一附属医院肝胆外科,陕西西安,710061
2. 山东烟台毓皇顶医院肝胆外科,山东,烟台,264000
3. 西安交通大学第二附属医院眼科,陕西,西安,710004
摘    要:目的 检测乙酰肝素酶(heparanase)和核转录因子κB(NF-κB p65)在胰腺癌中的表达,分析其与预后的关系并探讨NF-κB对调节heparanase的可能机制.方法 用免疫组化方法检测48例胰腺癌和26例癌旁组织中heparanase和NF-κB p65蛋白的表达,并分析与临床病理因素以及预后之间的关系.结果 heparanase和NF-κB在48例胰腺癌中的阳性表达率分别为62.5%和45.9%,显著高于癌旁组织.heparanase阳性表达与TNM分期(P=0.031)、淋巴结转移(P=0.003)呈正相关,与3年生存率呈负相关(20.0% vs 0%,P=0.001);NF-κB p65与淋巴结转移(P=0.017)、远处转移(P=0.031)正相关,与预后无相关.heparanase与NF-κB p65有较高的共同阳性表达率(P=0.018).多因素分析显示heparanase和NF-κB均非影响预后的独立因素.结论 heparanase在胰腺癌中表达增高且与预后不良相关,NF-κ可能上调heparanase表达水平,促进heparanase介导的肿瘤浸润转移.

关 键 词:乙酰肝素酶  胰腺肿瘤  核转录因子kappaB
文章编号:1673-4254(2007)08-1267-04
修稿时间:2007-04-12

Expression of heparanase and nuclear factor kappa B in pancreatic adenocarcinoma
WU Wu-jun,PAN Cheng-en,LIU Qing-guang,MENG Ke-wei,YU Hai-bo,WANG You-li,ZHAO Lin.Expression of heparanase and nuclear factor kappa B in pancreatic adenocarcinoma[J].Journal of Southern Medical University,2007,27(8):1267-1270.
Authors:WU Wu-jun  PAN Cheng-en  LIU Qing-guang  MENG Ke-wei  YU Hai-bo  WANG You-li  ZHAO Lin
Institution:Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. wuwujun_xa@163.com
Abstract:OBJECTIVE: To detect the expressions of heparanase and nuclear factor kappa B p65 (NF-kappaB p65) in pancreatic adenocarcinomas and analyze their relation to patients' prognosis and the regulatory mechanism of NF-kappaB on heparanase expression. METHODS: Heparanase and NF-kappaB p65 proteins in the tumor and adjacent tissues were detected by immunohistochemistry in 48 patients with pancreatic adenocarcinoma and analyzed for their clinicopathological significance. RESULTS: Heparanase and NF-kappaB p65 proteins were found in 30 (62.5%) and 22 (45.9%) tumor specimens, respectively, a rate significantly higher than that in the adjacent tissues. High heparanase expression was closely related to advanced TNM stage (P=0.031), lymph node metastasis (P=0.003) and decreased 3-year postoperative survival (20.0% vs 0%, P=0.001). NF-kappaB p65 expression was associated with lymph node metastasis (P=0.017) and distant metastasis (P=0.031), but had a higher positive rate in heparanase-positive cases than in heparanase-negative cases (P=0.018). Multivariate analysis showed that neither heparanase nor NF-kappaB p65 was the independent prognostic factors. CONCLUSION: Heparanase is overexpressed in pancreatic adenocarcinomas in association with decreased postoperative survival. NF-kappaB may up-regulate heparanase expression and promote heparanase-dependent tumor invasion and metastasis.
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