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| 河南林州食管癌家族史阳性患者比较基因组杂交特征 | |
| 引用本文： | 常志伟,王立东,秦艳茹,李苹娟,范宗民,郭涛,宋昕,王苒,李吉林,常志军,何欣.河南林州食管癌家族史阳性患者比较基因组杂交特征[J].南方医科大学学报,2009,29(6). |
| 作者姓名： | 常志伟 王立东 秦艳茹 李苹娟 范宗民 郭涛 宋昕 王苒 李吉林 常志军 何欣 |
| 作者单位： | 1. 河南省食管癌重点开放实验室,郑州大学第一附属医院,郑州大学基础医学院,河南,郑州,450052 2. 林州市姚村食管癌医院病理科,河南,林州,456592 3. 林州市中心医院胸外科,河南,林州,450092 |
| 基金项目： | 科技部863重大专项，河南省食管癌重点开放实验室基金 |
| 摘 要： | 目的 探讨河南食管癌高发区食管癌家族史阳性患者基因组变化特征.方法 应用比较基因组杂交技术分析13例食管癌家族史阳性和32例食管癌家族史阴性患者染色体基因组变化.结果 10q染色体部位DNA拷贝数扩增在食管癌家族史阳性患者为23%(3/13)而食管癌家族史阴性患者中无发生(P<0.05).15q染色体部位DNA拷贝数丢失在食管癌家族史阳性为38%(5/13),明显高于食管癌家族史阴性的6%(2/32)(P<0.05).3q、8q、7p、5p等染色体部位DNA拷贝数增加和3p、19q、9q等染色体部位DNA拷贝数丢失在食管癌家族史阳性和阴性患者中发生率均超过20%(P>0.05).结论 10q、15q可能存在与食管癌遗传高易感性相关的关键基因,而3q、8q、7p、5p、3p、19q、9q等可能存在与环境因素相关的食管癌关键基因. |
| 关 键 词： | 食管癌 比较基因组杂交 遗传易感性 家族史 |
Characterization of the changes in comparative genomic hybridization in esophageal cancer patients with family history |
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| CHANG Zhi-wei,WANG Li-dong,QIN Yan-ru,LI Pin-juan,FAN Zong-min,GUO Tao,SONG Xin,WANG Ran,LI Ji-ling,CHANG Zhi-jun,HE Xin.Characterization of the changes in comparative genomic hybridization in esophageal cancer patients with family history[J].Journal of Southern Medical University,2009,29(6). | |
| Authors: | CHANG Zhi-wei WANG Li-dong QIN Yan-ru LI Pin-juan FAN Zong-min GUO Tao SONG Xin WANG Ran LI Ji-ling CHANG Zhi-jun HE Xin |
| Institution: | CHANG Zhi-wei1,WANG Li-dong1,QIN Yan-ru1,LI Pin-juan2,FAN Zong-min1,GUO Tao1,SONG Xin1,WANG Ran1,LI Ji-ling1,CHANG Zhi-jun3,HE Xin1 1Henan Provincial Key Laboratory for Esophageal Cancer Research,First Affiliated Hospital,Basic Medical College,Zhengzhou University,Zhengzhou 450052,China,2Department of Pathology,Yaocun Esophageal Cancer Hospital,Linzhou 456592,3Department of Thoracic Surgery,Linzhou Central Hospital,Linzhou 450092 |
| Abstract: | Objective To characterize the profile of chromosomal imbalances in esophageal cancer (EC) with or without family history in Linzhou, Henan Province of China. Methods Comparative genomic hybridization (CGH) was used to examine 13 cases with positive family history of EC and 32 cases with negative family history of EC. Results DNA copy number gains on chromosome 10q was observed only in the cases with postivie family history of EC (30%), and none in cases with a negative family history (P<0.05). DNA copy numb... |
| Keywords: | esophageal cancer comparative genomic hybridization hereditary susceptibility family history |
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