首页 | 本学科首页   官方微博 | 高级检索  
检索        

T淋巴瘤侵袭转移诱导因子与大肠癌上皮间质转化的关系
引用本文:胡洁,王亚东,李余发,王雅娟,韩慧霞.T淋巴瘤侵袭转移诱导因子与大肠癌上皮间质转化的关系[J].南方医科大学学报,2009,29(2).
作者姓名:胡洁  王亚东  李余发  王雅娟  韩慧霞
作者单位:1. 南方医科大学病理系,广东,广州,510515
2. 南方医科大学南方医院消化病研究所,广东,广州,510515
摘    要:目的 探讨T淋巴瘤侵袭转移诱导因子1(Tiam1)与大肠癌上皮间质转化的关系.方法 应用免疫组化二步法检测143例大肠正常组织、大肠癌、大肠淋巴结转移癌石蜡组织标本中Tiam1、E-cadhefin、CK、vimemin的表达情况.结果 (1)Tiam1在大肠癌组织中表达显著高于正常组织(P<0.01),且与大肠癌分化程度有关(P<0.05);Tiam1在淋巴结转移癌中表达显著高于大肠癌原发灶(P<0.05);(2)E-cadherin、CK在大肠正常组织中表达高于癌组织(P<0.01),在大肠癌中的表达与分化程度有关(P<0.01),但在大肠癌与淋巴结转移癌中表达差异无显著性;(3)vimentin在大肠癌中表达比正常组织高(P<0.01),且与分化程度有关(P<0.01),但在大肠癌与淋巴结转移癌中表达无显著性差异;(4)Tiam1与E-cadherin、CK表达呈负相关,与vimentin表达呈正相关.结论 Tiam1与大肠癌分化和转移有关,其促进大肠癌转移的机制可能与上皮间质转化发生有关.

关 键 词:T淋巴瘤侵袭转移诱导因子1  上皮间质转化  大肠肿瘤  E-钙粘蛋白  细胞角蛋白  波形蛋白

Correlation between T lymphoma invasion and metastasis 1 expression and epithelial-mesenchymal transition in human colorectal carcinomas
HU Jie,WANG Ya-dong,LI Yu-fa,WANG Ya-juan,HAN Hui-xia.Correlation between T lymphoma invasion and metastasis 1 expression and epithelial-mesenchymal transition in human colorectal carcinomas[J].Journal of Southern Medical University,2009,29(2).
Authors:HU Jie  WANG Ya-dong  LI Yu-fa  WANG Ya-juan  HAN Hui-xia
Institution:HU Jie1,WANG Ya-dong2,LI Yu-fa1,WANG Ya-juan1,HAN Hui-xia1 Department of Pathology1,Institute of Digestive Diseases,Nanfang Hospital2,Southern Medical University,Guangzhou 510515,China
Abstract:Objective To investigate the relationship between T lymphoma invasion and metastasis 1 (Tiam1) and epithelial-mesenchymal transition (EMT) in human colorectal carcinomas. Method Tiam1, E-cadherin, CK, and vimentin expressions in normal colorectal epithelium, colorectal carcinomas (CRC) and CRC with lymphatic metastasis were determined by immunohistochemistry using a two-step method. Results Tiam1 expression was significantly higher in CRC than in normal colorectal epithelium (P<0.01) in close correlation to...
Keywords:T lymphoma invasion and metastasis 1  epithelial-mesenchymal transition  colorectal neoplasms  E-cadherin  cytokeratin  vimentin  
本文献已被 CNKI 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号