| 靶向药物载体-磁流体的制备及表面改性 |
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| 引用本文： | 阎玺庆,陈建海,蒋青锋,刘炜,西娜,吴志申.靶向药物载体-磁流体的制备及表面改性[J].南方医科大学学报,2005,25(6):626-629. |
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| 作者姓名： | 阎玺庆 陈建海 蒋青锋 刘炜 西娜 吴志申 |
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| 作者单位： | 1. 南方医科大学南方医院药学部,广东,广州,510515
2. 河南大学特种功能材料重点实验室,河南,开封,475001 |
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| 基金项目： | 国家高技术研究发展计划(863计划);国家自然科学基金 |
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| 摘 要： | 应用化学共沉淀法制得以Fe3O4为母核的磁流体,并用葡聚糖-70对其进行表面改性,同时对用葡聚糖改性后的磁流体在强碱条件下链接6个碳的有机物链,考察其化学和物理稳定性,并利用现代分析手段如激光粒度仪、FT-IR、XRD、TEM等对其进行表征。经过处理后的磁流体具有很强的耐酸碱能力,外观、稳定性和母核结构未发生明显变化。表面葡聚糖的存在大大增加了磁流体的稳定性,适合在苛刻条件下用作药物载体或者进一步与具有相应活性基团的药物相结合。
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| 关 键 词： | 磁流体 葡聚糖-70 纳米粒 表面改性 |
| 文章编号： | 1000-2588(2005)06-0626-04 |
| 修稿时间： | 2004年11月3日 |
Preparation and surface modification of the magnetic fluid as a targeted drug carrier |
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| YAN Xi-qing,CHEN Jian-hai,JIANG Qing-feng,LIU Wei,Xi Na,WU Zhi-shen.Preparation and surface modification of the magnetic fluid as a targeted drug carrier[J].Journal of Southern Medical University,2005,25(6):626-629. |
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| Authors: | YAN Xi-qing CHEN Jian-hai JIANG Qing-feng LIU Wei Xi Na WU Zhi-shen |
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| Abstract: | Magnetic fluid containing Fe3O4 as mother nucleus was prepared by chemical coprecipitation and treated with dextran-70 for surface modification. The dextran-70-modified magnetic fluid was reacted with 6-bromohexanoic acid and their chemical stability was studied, with the structure characterized by using laser granulometer, X-ray diffraction, Fourier-transform infrared analysis and transmission electron microscopy. The results showed that the magnetic fluid with surface modification by dextran-70 exhibited high stability in the presence strong alkali or acid. No chemical changes occurred in the magnetic Fe3O4 nucleus surrounded by alkali-treated dextran-70 and the organic chain linked to the surface dextran rendered the reaction to the anti-cancer drug such as mitomycin C possible, suggesting the potential of the preparation as a drug carrier. |
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| Keywords: | magnetic fluid dextran-70 nanoparticles surface modification |
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