| 不同浓度的尼可地尔对心肌细胞膜KATP通道的影响 |
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| 引用本文： | 冯力,刘伊丽,刘杰,邓英姿,袁勇,马立勤,赖文岩.不同浓度的尼可地尔对心肌细胞膜KATP通道的影响[J].南方医科大学学报,2000,20(1):32-35. |
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| 作者姓名： | 冯力 刘伊丽 刘杰 邓英姿 袁勇 马立勤 赖文岩 |
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| 作者单位： | 1. 第一军医大学南方医院心内科,广东,广州,510515
2. 第一军医大学病理生理教研室,广东,广州,510515 |
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| 摘 要： | 本实验在急性分离的豚鼠心肌细胞上,用膜片钳技术单通道记录的内面向外记录模式研究了不同浓度的尼可地尔对细胞膜KATP通道的影响.结果证实:0.1 mM的该药物不能激活KATP通道,而1 mM 的药物可明显激活细胞膜KATP通道.其电导为92.7 pS,通道的开放时间常数τO2 和开放概率较对照组(加入0 .5 mM ATP)明显增加,并可诱发通道出现二级开放.表明尼可地尔对心肌细胞膜KATP通道呈剂量依赖性激活.
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| 关 键 词： | 尼可地尔 心肌细胞 KATP通道 |
The effect of different dose of KATP channel opener on the cardiac plasma membrane KATP channel nicorandil |
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| FENG Li,LIU Yi-li,LIU Jie,DENG Ying-zi,YUAN Yong,MA Li-qin,LAI Wen-yan.The effect of different dose of KATP channel opener on the cardiac plasma membrane KATP channel nicorandil[J].Journal of Southern Medical University,2000,20(1):32-35. |
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| Authors: | FENG Li LIU Yi-li LIU Jie DENG Ying-zi YUAN Yong MA Li-qin LAI Wen-yan |
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| Abstract: | Objective To study the effect on cardiac plasma membrane (CPM) K_ATP channel of isolated ventricular myocytes of different dose of K_ATP channel opener, nicorandil (NIC). Method Single channel patch clamp technique was used. Result it was showed that CPM K_ATP channel current could not be activated by 0. 1 mM NIC, but which could be remarkably induced by 1 mM NIC, and the conductance of K_ATP channel current activated by NIC was 92.7 pS. The slow time constant of the open time and the open state probability (Po) were increased compared with control group, and the secondary opening of K_ATP channel was induced by NIC, Conclusion NIC can affect CPM in a dose-dependent manner |
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| Keywords: | nicorandi ventricular myocytes K_ATP channel |
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