首页 | 本学科首页   官方微博 | 高级检索  
检索        

瞬时弹性记录仪检测肝纤维化影响因素及稳定性分析
引用本文:李林芳,戴琳,张琪,陈永鹏,冯筱榕,郭亚兵,侯金林.瞬时弹性记录仪检测肝纤维化影响因素及稳定性分析[J].南方医科大学学报,2008,28(4):595-597.
作者姓名:李林芳  戴琳  张琪  陈永鹏  冯筱榕  郭亚兵  侯金林
作者单位:南方医科大学南方医院感染内科,广东,广州,510515
摘    要:目的 探讨影响瞬时弹性记录仪FibroScan(R)测量肝纤维化成功率因素及其重复性.方法 用FibroScan(R)对637例健康人群、慢性乙肝病毒携带者、慢性肝炎和肝硬化患者共进行939次系列肝脏硬度测量.其中302例受检者进行了2次系列检测.对同一检测对象,两位操作者分别检测或同一操作者分别进行2次系列检测,每系列检测取10个检测值. 取中位数为最终检测值.分析评价体质量指数、性别、年龄、疾病状态等对检测成功率的影响,组内相关系数(ICC)评价FibroScan(R)检测结果 的可重复性.结果 14例无法获得弹性值,失败率为2.2%.失败率与疾病状况无关,质量指数高将使成功率降低(t=3.112,P=0.002).女性成功率较男性低(t=-2.193,P=0.029).对同一检测对象,同一操作者多次操作或不同操作者进行FibroSear(R)检测,ICC分别为0.970、0.847;对于健康和慢性乙肝病毒携带受检者,FibroScan(R)检测稳定性下降(ICC分别为0.736、0.639).既往肝硬化并发症病史及高肝功能Child-Pugh评分将使肝硬化患者FibroScan(R)弹性值升高.结论 FibroScan(R)检测慢性肝病患者肝纤维化程度稳定性良好;高体质量指数降低操作成功率:高弹性值可能预测肝硬化并发症及肝功能代偿状态.

关 键 词:FibroScan(R)  肝纤维化  肝硬化  瞬时弹性记录仪  高弹性  记录仪  检测  肝纤维化程度  化影响因素  稳定性  分析  evaluation  liver  fibrosis  elastography  transient  stability  rate  success  状态  功能代偿  预测  肝病患者  慢性  评分
文章编号:1673-4254(2008)04-0595-03
修稿时间:2007年10月15

Factors influencing the success rate and stability of transient elastography for liver fibrosis evaluation
LI Lin-fang,DAI Lin,ZHANG Qi,CHEN Yong-peng,FENG Xiao-rong,GUO Ya-bing,HOU Jin-lin.Factors influencing the success rate and stability of transient elastography for liver fibrosis evaluation[J].Journal of Southern Medical University,2008,28(4):595-597.
Authors:LI Lin-fang  DAI Lin  ZHANG Qi  CHEN Yong-peng  FENG Xiao-rong  GUO Ya-bing  HOU Jin-lin
Institution:Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. linfangli80@hotmail.com
Abstract:OBJECTIVE: To investigate the factors influencing the success rate and stability of transient elastography(FibroScan)for assessment of liver fibrosis. METHODS: Liver stiffness was assessed using transient elastography in totally 637 subjects including healthy subjects, asymptomatic hepatitis B virus (HBV) carriers, patients with chronic hepatitis B and patients with HBV-related cirrhosis. Of these subjects, 302 received 2 examinations and totalling 939 examinations were performed. In each case, one operator performed 2 consecutive series of 10 validated measurements, or 2 operators performed a series of 10 validated measurements. The factors including gender, age, body mass index (BMI) and the state of diseases were analyzed for their association with the success of the examination. Intraclass correlation coefficient (ICC) was used to evaluate the reproducibility of the operation. RESULTS: Failure of the measurement occurred in 14 cases (2.2%), which was not associated with the age of the subjects and the state of diseases. The success rate of measurement decreased as the BMI increased (t=3.112, P=0.002), and was lower in female subjects (t=-2.193, P=0.029). The intra- and inter-operator stability of liver stiffness measurement was satisfactory, with ICC of 0.970 and 0.847, respectively. But for healthy subjects and asymptomatic HBV carriers, the stability was lower, with ICC of 0.736 and 0.639, respectively. Liver stiffness in patients with liver cirrhosis was positively correlated to complications and Child-Turcotte-Pugh (CTP) score. CONCLUSION: Liver stiffness measurement has high stability with FibroScan, and high BMI could lower success rate of the measurement. Liver stiffness as measured by FibroScan allows prediction of the liver function and presence of complications in patients with liver cirrhosis.
Keywords:FibroScan R  fibrosis  cirrhosis  transient elastography  
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号