| 正常人静脉血流阻断后血浆组织型纤溶酶原激活剂含量、活性及其抑制物活性的变化 |
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| 引用本文： | 贾海燕,王结义,宋后燕,陈灏珠,顾天爵,浦寿月,诸骏仁.正常人静脉血流阻断后血浆组织型纤溶酶原激活剂含量、活性及其抑制物活性的变化[J].复旦学报(医学版),1987(5). |
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| 作者姓名： | 贾海燕 王结义 宋后燕 陈灏珠 顾天爵 浦寿月 诸骏仁 |
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| 作者单位： | 上海市心血管病研究所，基础医学部生物化学教研室，基础医学部生物化学教研室，上海市心血管病研究所，基础医学部生物化学教研室，上海市心血管病研究所，上海市心血管病研究所 上海医科大学中山医院，上海医科大学中山医院，上海医科大学中山医院，上海医科大学中山医院 |
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| 摘 要： | 用酶联免疫吸附法(ELISA)和比色分析法测定了20名正常人血浆组织型纤溶酶原激活剂(Tissue plasminogen activator,tPA)的含量、活性及纤溶酶原激活剂抑制物(Plasminogen activator inhibitor,PAI)的活性。检测到正常人在静脉血流阻断后,血浆tPA含量、活性均有显著增高,PAI活性变化不大。讨论了血浆tPA和PAI测定的临床意义。
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| 关 键 词： | 组织型纤溶酶原激活剂 纤溶酶原激活剂抑制物 血浆含量 静脉血流阻断 |
ALTERATIONS IN PLASMA LEVELS OF TISSUE PLASMINOGEN ACTIVATOR AND ITS INHIBITOR AFTER VENOUS OCCLUSION IN NORMAL SUBJECTS |
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| Jia Haiyan,Wang Jieyi,Song Hoayan,Ohea Haozhu,Pu Shouyue,Gu Tianjue,Zhu Junren.ALTERATIONS IN PLASMA LEVELS OF TISSUE PLASMINOGEN ACTIVATOR AND ITS INHIBITOR AFTER VENOUS OCCLUSION IN NORMAL SUBJECTS[J].Fudan University Journal of Medical Sciences,1987(5). |
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| Authors: | Jia Haiyan Wang Jieyi Song Hoayan Ohea Haozhu Pu Shouyue Gu Tianjue Zhu Junren |
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| Abstract: | The plasma levels of tissue plasminogen activator (tPA) antigen, tPA activity, and plasminogen activator inhibitor (PAI) were dotermined in 20 normal subjects by the enzyme linked immunosorbent assay (ELISA) and the spectrophotometric assays, respectively. It was found that the plasma levels of tPA antigen and tPA activity were significantly increased after a 10 minutes' oompressive venous occlusion of the arm (p<0.001), while there was no significant change in that of PAI (p> 0.05). Tke clinical implications of plasma tPA antigen, tPA activity, and PAI determinations are discussed. |
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| Keywords: | tissue plasminogen activator plasminogen activator inhibitor plasma levels: venous occlusion |
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