Hippo信号通路与肾脏损伤修复的研究进展

 Hippo信号通路在进化上高度保守，参与多种人类疾病的发生发展。近年研究发现，在肾脏损伤修复过程中Hippo信号通路具有重要作用。在急性肾损伤（acute kidney injury，AKI）的早期，Hippo信号通路的失活有助于幸存肾小管上皮细胞增殖，促进肾小管的再生。而在AKI中后期，Hippo通路的持续失活则可能诱导AKI向慢性肾脏病（chronic kidney disease，CKD）转化。因此，对肾脏内Hippo信号通路的全面了解将有助于发现新的AKI治疗靶标和治疗策略。本文总结了AKI后Hippo通路促进肾脏适应性修复的潜在机制，并讨论了Hippo通路的持续失活可能对肾脏不良修复和向CKD演化的影响。

Research progress of Hippo pathway in renal injury and repair

Hippo pathway is highly evolutionarily conserved and is associated with the development and advances of various human diseases.In recent years,studies have shed light on the significant role of Hippo pathway in kidney injury and repair.Some data point out the Hippo pathway loss promotes proliferation and regeneration of tubular epithelial cells after acute kidney injury (AKI).However,other evidence shows that the persistent inactivation of Hippo pathway in the post-acute phase of AKI may induce the transition of AKI to chronic kidney disease (CKD).Therefore,a comprehensive understanding of the functional contribution of Hippo pathway in the repair of AKI and the development of CKD will help to discover new therapeutic targets and strategies for AKI.In this review,we summarize how Hippo pathway regulates adaptive repair after AKI and discuss how sustained inactivation of Hippo pathway triggers maladaptive responses and causes CKD progression.