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| 寨卡病毒感染的辅助性宿主因子研究进展 | |
| 引用本文： | 郭娇菡,徐建青.寨卡病毒感染的辅助性宿主因子研究进展[J].复旦学报(医学版),2021,49(1):144-148. |
| 作者姓名： | 郭娇菡 徐建青 |
| 作者单位： | 1. 上海市(复旦大学附属)公共卫生临床中心 上海 201508; 2. 复旦大学生物医学研究院 上海 200032 |
| 基金项目： | 国家自然科学基金青年项目（81901598） |
| 摘 要： | 寨卡病毒(Zika virus，ZIKV)感染可造成宿主神经系统损伤，与胎儿头小畸形和格林-巴利综合征的发生相关。有许多针对包括ZIKV在内的黄病毒疫苗与抗病毒药物正处于研发阶段。本文总结了辅助ZIKV感染的宿主因子研究现状，有助于揭示ZIKV的感染机制。 |
| 关 键 词： | 寨卡病毒(ZIKV) 黄病毒 生命周期 病毒-宿主相互作用 |
| 收稿时间： | 2021-02-22 |
Research progress on host factors facilitating Zika virus infection |
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| GUO Jiao-han,XU Jian-qing.Research progress on host factors facilitating Zika virus infection[J].Fudan University Journal of Medical Sciences,2021,49(1):144-148. | |
| Authors: | GUO Jiao-han XU Jian-qing |
| Institution: | 1. Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China; 2. Institute of Biomedical Science, Fudan University, Shanghai 200032, China |
| Abstract: | The infection of Zika virus (ZIKV) can be detrimental to host nervous system, leading to fetal microcephaly and Guillain-Barré syndrome.Researches are focusing on the development of vaccines and drugs targeting flaviviruses including ZIKV.This paper reviewed the present research status of the host factors which facilitates the infection of ZIKV so as to uncover the mechanism of ZIKV infection. |
| Keywords: | Zika virus (ZIKV) flavivirus life cycle virus-host interaction |
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