| 索拉非尼治疗转移性肾癌的疗效评估与不良反应（附3例报告和文献复习） |
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| 引用本文： | 张正望,钱伟庆,单哉,孙忠全.索拉非尼治疗转移性肾癌的疗效评估与不良反应（附3例报告和文献复习）[J].复旦学报(医学版),2009,36(1):93-96. |
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| 作者姓名： | 张正望 钱伟庆 单哉 孙忠全 |
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| 作者单位： | 复旦大学附属华东医院泌尿外科，上海，200040 |
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| 摘 要： | 目的 以分子靶向药物索拉非尼治疗转移性肾癌（metastatic renal cell carcinoma,mRCC），国内临床经验有限。本文探讨索拉非尼疗效评估的特点及药物不良反应的特征和处理。方法 回顾性分析我院应用索拉非尼治疗3例mRCC的临床资料，并作文献复习。结果 采用实体瘤治疗反应评价标准评估3例疗效均为病情稳定，肺转移灶的缩小或数目减少较原发灶和其他转移灶显著；药物不良反应为手足皮肤反应（HFSR）、谷丙转氨酶（ALT）异常和高血压等。结论 索拉非尼的疗效不宜以传统的肿瘤缓解标准来衡量，熟悉不良反应的特征及处理方法对持续用药有重要意义。
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| 关 键 词： | 肾细胞癌 转移 靶向治疗 索拉非尼 |
| 收稿时间： | 2008-7-7 |
The therapeutic evaluation and adverse effects of sorafenib in treating metastatic renal cell carcinoma(with 3 cases report and literature review) |
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| ZHANG Zheng-wang,QIAN Wei-qing,SHAN Zai,SUN Zhong-quan.The therapeutic evaluation and adverse effects of sorafenib in treating metastatic renal cell carcinoma(with 3 cases report and literature review)[J].Fudan University Journal of Medical Sciences,2009,36(1):93-96. |
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| Authors: | ZHANG Zheng-wang QIAN Wei-qing SHAN Zai SUN Zhong-quan |
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| Institution: | Departrnmt of Urology, Huadong Hospital, Fudan University, Shanghai 200040, China |
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| Abstract: | Objective Clinical experiences in treating metastatic renal cell carcinoma(mRCC) using sorafenib are limited in China.The objectives of this article were to investigate and discuss the therapeutic evaluation of sorafenib in the treatment of mRCC,the drug related adverse events and their responsible managements. Methods The clinical data of 3 mRCC patients treated with sorafenib in our hospital were analyzed retrospectively.Related literatures were reviewed. Results All cases achieve stable disease(SD) accor... |
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| Keywords: | renal cell carcinoma metastasis targeted therapy sorafenib |
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