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黄芪多糖对NOD小鼠1型糖尿病的预防作用
引用本文:陈蔚,刘芳,俞茂华,朱秋毓,朱禧星.黄芪多糖对NOD小鼠1型糖尿病的预防作用[J].复旦学报(医学版),2001,28(1):57-60.
作者姓名:陈蔚  刘芳  俞茂华  朱秋毓  朱禧星
作者单位:复旦大学附属华山医院内分泌科
基金项目:上海市卫生局中医药科研基金(982029)资助项目
摘    要:目的 探讨黄芪多糖对NOD小鼠1型糖尿病的预防作用。方法 比较APS预免疫组NOD小鼠和NS对照组NOD小鼠DM发病率、血清C-P和GAD-Ab水平、脾脏T细胞亚群比例、胰岛组织病理学和免疫组化。结果 APS组与NS组比较,DN发病率显著降低,血清C-P水平显著增高,胰岛炎症程度减轻,CD8T细胞亚群比例显著增高,CD4/CD8比值显著降低。结论 早期应用黄芪多糖预免疫可以预防或延缓NOD小鼠1型糖尿病的发病。

关 键 词:黄芪多糖  I型糖尿病  免疫  NOD小鼠  预防
修稿时间:2000年4月18日

Astragalus Polysaccharide Prevent Type 1 Diabetes in Nonobese Diabetic Mice
CHEN Wei,LIU Fang,YU Mao-hua,ZHU Qiu-yu,ZHU Xi-xing.Astragalus Polysaccharide Prevent Type 1 Diabetes in Nonobese Diabetic Mice[J].Fudan University Journal of Medical Sciences,2001,28(1):57-60.
Authors:CHEN Wei  LIU Fang  YU Mao-hua  ZHU Qiu-yu  ZHU Xi-xing
Abstract:Purpose To observe the effects of the intervention or prevention of astragalus polysaccharide(APS)on type 1 diabetes in non obese diabetic(NOD) mice. Methods the APS group was compared with the normal solution(NS)group by the incidence of diabetes,the serum C peptide levels and GAD Ab levels,the proportion of CD 4 or CD 8 T subsets in splencytes,pancreatic histopathology and immunocyto chemistry. Results It shows that the APS group has lower incidence of diabetes,higher serum C?P levels,decreased degree of the lymphocytic inflammation of pancreatic islets,stronger proliferation of CD 8 T subsets and lower ratio of CD 4/CD 8 subgroup in splencytes than those of the NS group. Conclusions It proves the preventive effects of APS on the onset of type 1 diabetes in NOD mice.
Keywords:astragalus polysaccharide  type 1 diabetes  immunology
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