首页 | 本学科首页   官方微博 | 高级检索  
检索        

肾小球滤过率的相关因素分析及新测算公式的创建
引用本文:吴锡信,陈江林,彭健.肾小球滤过率的相关因素分析及新测算公式的创建[J].复旦学报(医学版),2002,29(4):300-301,305.
作者姓名:吴锡信  陈江林  彭健
作者单位:1. 中山大学附属第五医院肾内科
2. 中山大学附属第五医院心内科
3. 暨南大学医学院附属珠海市人民医院核医学科,珠海,519000
基金项目:珠海市医学科研基金资助项目 ( 2 0 30 -30 )
摘    要:目的 创建准确、简便、安全、价廉的测算肾小球滤过率 (GFR)新公式。方法 用99mTc DTPA清除率准确测定 12 2例受试者GFR(Tc GFR) ,同时测定血清肌酐 (SCr)等多种临床指标 ,经相关及回归分析 ,求出测算GFR(MC GFR)公式。以此公式测算另选的 83例受试者MC GFR ,并用Cockcroft/Gault公式测算其肌酐清除率(MC CCr)。结果 所求得的公式成立 ,其回归系数有显著性 (P <0 .0 0 0 1) ,lgMC GFR、lgMC CCr均与lgTc GFR有显著正相关 (P <0 .0 1~ 0 .0 5 ) ,但MC GFR与Tc GFR间无显著差异 (P >0 .0 5 ) ,而MC GFR与Tc GFR间则有显著差异 (P <0 .0 1)。结论 MC GFR可代替Tc GFR ,且准确、简便、安全、价廉 ,值得推广应用

关 键 词:肾小球滤过率  99mTc-DTPA清除率  肌酐清除率  肾功能

Analysis of the Relative Factors of Glomerular Filtration Rate and Establishing the New Formula for Measurement and Calculation
Abstract:Purpose To establish an accurate,simple,safe and cheap new formula for measurement and calculation of glomerular filtration rate (GFR). Methods GFR from 122 cases of patient were determined accurately using Clearance of 99mTc-DTPA(Tc-GFR).Many clinical factors for example serum creatinine(SCr) and so on were determined simultaneously using routine method.The equation was obtained by the relationship and regression analysis for measurement and calculation GFR(MC?GFR).MC?GFR from another 83 cases of patient were measured and calculated by this equation and the creatinine clearance rate (CCr) were measured and calculated by Cockcroft/Gault formula(MC?CCr). Results The equation was tenable and the regression coefficient was signif- icantly (P<0.000 1).There were positive correlation significantly among lgMC?GFR,lgMC?CCr and lgTc-GFR(P<0.01-0.05).But there was no difference significantly between MC?GFR and Tc-GFR(P>0.05) and there was difference significantly between MC?CCr and Tc-GFR(P<0.01). Conclusions MC?GFR could replace Tc-GFR and MC?GFR was accurate,simple,safe and cheap and it should apply and popularize.
Keywords:glomerular filtration rate  clearance of      99mTc-DTPA  creatinine clearance  renal function
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号