线粒体动力学与心肌细胞能量代谢的研究进展

 【摘要】线粒体是一种高度动态变化的细胞器,通过不断地融合 分裂维持线粒体网络的稳态,线粒体融合 分裂的动态平衡对心肌细胞能量代谢和收缩功能的维持起着至关重要的作用。线粒体动力学在心血管疾病中的作用机制尚不明确,越来越多的证据表明,线粒体动力学变化参与扩张型心肌病、缺血 再灌注损伤、心力衰竭等心血管疾病的病理过程。本文围绕线粒体融合 分裂失衡与心肌细胞能量代谢的关系作简要综述。

Advance on the relationship between mitochondrial dynamics and myocardial energy metabolism

【Abstract】Mitochondria are highly dynamic organelles that continuously undergo fusion and fission to adapt the energy metabolism of myocardial cells and to maintain their systolic function.However,the functional role of mitochondrial dynamics in the heart remains unclear.Emerging evidence suggests that mitochondrial dynamics may contribute to the pathologic processes of dilated cardiomyopathy,ischemia-reperfusion injury and heart failure.This article is to briefly review impaired balance of mitochondrial fission and fusion on the energy metabolism of myocardial cells.