靶向肿瘤微环境(TME)免疫治疗策略的研究进展

 肿瘤微环境（tumor microenvironment，TME）在肿瘤恶性进展、免疫逃逸和治疗抵抗中发挥重要作用。根据TME特点开发安全有效的免疫疗法是目前抗肿瘤技术研究的热点，同时个体化TME特征作为免疫治疗耐受的主因，有待发掘合理的适用人群和联合治疗方案，以便优化现有的免疫治疗策略。本文对TME特征、免疫状态及肿瘤免疫治疗策略的研究进展进行综述，通过深入理解多元化的TME和免疫策略，为个体的精准化免疫治疗提供线索和依据。

The impact of the progressive rehabilitative program on ipsilateral range of motion and quality of life of the breast cancer patients after modified radical mastectomy

Tumor microenvironment (TME) plays an important role in tumor progression,immune escape and drug resistance.Recently,much attention has been paid on developing more effective immunotherapies with safety considerations based on the characteristics of TME.However,current immunotherapies can initiate resistance gradually due to the complexity TMEs of individuals,and fail to get ideal outcomes.Thus it is imperative to optimize the existing immunotherapy strategies by combining potential treatments and selecting appropriate population.Here we reviewed literatures to generally understand individual tumor conditions through the characteristics of TME,immunological conditions and related immunotherapy strategies,for further indicating the immunological intervention of killing tumors precisely.