| 甲状腺髓样癌CD44V6表达与颈淋巴结转移的关系 |
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| 引用本文： | 黄彩平,朱永学,施达仁,陆洪芬.甲状腺髓样癌CD44V6表达与颈淋巴结转移的关系[J].复旦学报(医学版),2001,28(6):523-525. |
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| 作者姓名： | 黄彩平 朱永学 施达仁 陆洪芬 |
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| 作者单位： | 1. 复旦大学附属肿瘤医院头颈外科,
2. 复旦大学附属肿瘤医院病理科, |
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| 摘 要： | 目的 探讨甲状腺髓样癌CD44V6表达与颈淋巴结转移的关系。方法 应用免疫组Envision法对36例伴颈淋巴结转移的甲状腺髓样癌（MTC＋LNM）、13例无颈淋巴结转移的甲状腺髓样癌（MTC）、甲状腺滤泡型癌（FTC）和正常甲状腺组织（NT）各21例进行CD44V6检测。结果 正常甲状腺组织中无CD44V6表达，甲状腺髓样癌和甲状腺滤泡型癌中均有CD44V6表达，但MTC＋LNM组的CD44V6阳性表达明显高于MTC组和FTC组（P＜0．05，P＜0．01）。结论 CD44V6在甲状腺髓样癌中有异常表达，且伴有颈淋巴结转移的甲状腺髓样癌CD44V6高表达，说明CD44V6阳性表达与其颈淋巴结转移关系密切，对颈淋巴结转移起促进作用。
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| 关 键 词： | 甲状腺髓样癌 CD44V6 免疫组化 淋巴结转移 |
| 修稿时间： | 2001年6月11日 |
Relationship between Expression of CD44V6 in Medullary Thyroid Carcinoma and Its Cervical Lymph Node Metastasis |
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| Abstract: | Purpose To explore the relation between the expression of CD44V6 in medullary thyroid carcinoma and its cervical lymph node metastases. Methods By immunohistochemical method,CD44V6 was detected in 36 MTC with LNM,13 MTC,21 FTC and 21 NT. Results No expression was observed in normal thyroid tissues,positive expression was observed in MTC and FTC.But positive expression of CD44V6 in MTC with LNM was significantly higher than in MTC without LNM and FTC( P <0.05, P <0.01). Conclusions Overexpression of CD44V6 in MTC,especially in MTC with LNM,is correlated with regional lymph node metastases,and it may promote lymph node metastases of medullary thyroid carcinoma. |
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| Keywords: | medullary thyroid carcinoma CD44V6 immunohistochemistry metastasis |
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