| 冠心病、高脂血症和低高密度脂蛋白血症患者载脂蛋白Al基因的多态性 |
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| 引用本文： | 严建,陈灏珠,宋后燕,林佑善,韩琴琴.冠心病、高脂血症和低高密度脂蛋白血症患者载脂蛋白Al基因的多态性[J].复旦学报(医学版),1990(4). |
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| 作者姓名： | 严建 陈灏珠 宋后燕 林佑善 韩琴琴 |
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| 作者单位： | 上海医科大学中山医院上海市心血管病研究所
(严建，陈灏珠，林佑善)，上海医科大学中山医院分子遗传学研究所
(宋后燕)，上海医科大学中山医院上海市心血管病研究所(韩琴琴) |
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| 基金项目： | 国家自然科学基金1989准字第(3880412) |
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| 摘 要： | 本实验用分析基因限制性内切酶片段长度多态性(Restriction fragment length olymorphisms,RFLPs)技术,检测到中国人载脂蛋白AI(Apolipoprotein AI。Apo AI)基因3′端存一PstI多态位点,并发现该多态位点与低高密度脂蛋白(HDL)血症及冠心病有较密切的关系。
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| 关 键 词： | 载脂蛋白AI基因 限制性内切酶片段长度多态性 冠心病 高脂血症 低高密度脂蛋白血症 |
POLYMORPHISM OF APOLIPOPROTEIN AI GENE IN CORONARY HEART DISEASE,HYPERLIPIDAEMIA AND HYPOALPHALIPOPROTEINEMIA PATIENTS |
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| Yan Jian,Ohen Haozhu,Song Houyan,Lin Youshan,Han Qinqin.POLYMORPHISM OF APOLIPOPROTEIN AI GENE IN CORONARY HEART DISEASE,HYPERLIPIDAEMIA AND HYPOALPHALIPOPROTEINEMIA PATIENTS[J].Fudan University Journal of Medical Sciences,1990(4). |
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| Authors: | Yan Jian Ohen Haozhu Song Houyan Lin Youshan Han Qinqin |
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| Abstract: | Using restriction fragment length polymorphisms (RFLPs) technique, we have detected a Pst I polymorphic site which is at the 3' end of apolipoprptein AI (Apo AI) gene in Chinese. In the population studied, significant differences in allele frequency were observed between subjects suffering from coronary heart disease, hypoalpha-lipoproteinemia and controls. |
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| Keywords: | apolipoprotein AI gene restretion fragment length polymorphisms coronary heart disease hyperlipidaemia hypoalpha-lipoproteinemia |
| 本文献已被 CNKI 等数据库收录！ |
