| 反义脱氧寡核苷酸对SRS病毒复制的抑制作用 |
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| 引用本文： | 单易非,纪宏,裘慕绥,王德宝.反义脱氧寡核苷酸对SRS病毒复制的抑制作用[J].复旦学报(医学版),1990(6). |
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| 作者姓名： | 单易非 纪宏 裘慕绥 王德宝 |
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| 作者单位： | 上海医科大学基础医学部生物物理学教研室
(单易非，纪宏)，中国科学院上海生物化学研究所
(裘慕绥)，中国科学院上海生物化学研究所(王德宝) |
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| 摘 要： | 用合成的反义脱氧寡核苷酸,包括修饰的和非修饰的,同聚的和异聚的脱氧寡核苷酸对SRS病毒感染细胞的增殖、细胞群落形成,XC融合细胞产生的抑制作用。结果表明,上述的寡聚物对病毒都有抑制活性。各种寡聚物的作用机制不同。
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| 关 键 词： | 反义寡核苷酸 竞争性杂交 抗病毒作用 寡聚物 |
INHIBITION OF SRS VIRUS REPLICATION BY ANTISENSE OLIGODEOXYNUCLEOTI DES |
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| Shan Yifei,Ji Hong,Qiu Musui,Wang Debao.INHIBITION OF SRS VIRUS REPLICATION BY ANTISENSE OLIGODEOXYNUCLEOTI DES[J].Fudan University Journal of Medical Sciences,1990(6). |
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| Authors: | Shan Yifei Ji Hong Qiu Musui Wang Debao |
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| Abstract: | Synthesized antisense oligodeoxynuoleotides, including their modified and unmodified,homo-and hetero forms were tested for their ability to inhibit mouse SRS virus-induced cellular multiplication, formations of colonies of SRSV-infected cells and XC synoytia. All oligomers were found to be active. Results Suggest that different classes of oligonuoleotidee inhibit virus replication by different mechanisms. |
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| Keywords: | antisense oligonucleotides competitive hybridization oligomer antivirals |
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