| PD-1/PD-L通路在食管癌中的表达及临床意义的研究进展 |
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| 引用本文： | 马可.PD-1/PD-L通路在食管癌中的表达及临床意义的研究进展[J].复旦学报(医学版),2018,45(3):408-412. |
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| 作者姓名： | 马可 |
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| 作者单位： | 复旦大学附属中山医院胸外科 上海 200032 |
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| 基金项目： | 国家自然科学基金(81401875);上海市自然科学基金(14ZR1406000);上海市卫计委科研课题(201640102) |
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| 摘 要： | 程序性死亡分子1及配体(programmed death-1/programmed death-1 ligand,PD-1/PD-L)的信号通路是肿瘤免疫逃逸的重要机制之一,针对这一通路的靶向药物已应用于一些肿瘤的临床治疗并取得了良好疗效。近年来,PD-1/PD-L通路在食管癌中的研究有一定的进展,初步探索了PD-1/PD-L通路在食管癌中的表达和临床意义。本文综述了PD-1/PD-L通路在食管癌中的研究成果,以期为食管癌的治疗提供新的思路。
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| 关 键 词： | 程序性死亡分子1 程序性死亡分子配体 食管癌 |
The progress on expression and clinical significance of PD-1/PD-L pathway in esophageal cancer |
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| MA Ke,YANG Xiao-dong,SUN Feng-hao,ZHAN Cheng,WANG Qun.The progress on expression and clinical significance of PD-1/PD-L pathway in esophageal cancer[J].Fudan University Journal of Medical Sciences,2018,45(3):408-412. |
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| Authors: | MA Ke YANG Xiao-dong SUN Feng-hao ZHAN Cheng WANG Qun |
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| Institution: | Department of Thoracic Surgery,Zhongshan Hospital,Fudan University,Shanghai 200032,China |
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| Abstract: | Programmed death-1/programmed death-1 ligand (PD-1/PD-L) signal pathway plays an important role in tumor immune evasion.PD-1/PD-L blockade represented one of the most promising strategies of some tumor immunotherapy.Recently,more and more researches revealed the clinical significant of PD-1/PD-L signal pathway in esophageal cancer.This review briefly summarizes the research progress of PD-1/PD-L signal pathway in esophageal cancer,in order to provide some new methods in esophageal cancer immunotherapy. |
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| Keywords: | programmed death-1 programmed death-1 ligand esophageal cancer |
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