线粒体动力学与肿瘤的研究进展

 线粒体动力学是指线粒体处在融合(fusion)与裂解(fission)的动态平衡中,线粒体的这种动态变化,可表现为形态上的异质性,在胞质中可呈点状、碎片状、条状或线状等不同形态。线粒体动力学与线粒体的功能有密切联系,如细胞增殖、细胞代谢、细胞迁移等,并受多种化学酶及蛋白质的调控。在肿瘤中存在线粒体动力学的失调,线粒体动力学相关蛋白在肿瘤中表达异常,而且线粒体动力学相关蛋白与患者的预后及生存时间相关。线粒体动力学状态的改变可影响肿瘤的发生、发展及转移,但具体机制尚不明确。

Research progress of mitochondrial dynamics and cancer

Mitochondrial dynamics refers to the balance of fusion and fission in mitochondrial network,the change of mitochondrial dynamics lead to mitochondrial morphological heterogeneity,can be characterized as punctuated,fragmented or linear,tubular mitochondrial in the cytoplasm.Mitochondrial dynamics is closely associated with mitochondrial function,such as cell proliferation,cell metabolism,cell migration,and it is controlled by a variety of chemical enzymes,protein and cytokines.Accumulative evidence is beginning to reveal the close links between cancers and unbalanced mitochondrial dynamics.The expression of mitochondrial dynamic related proteins is dysregulated in human cancers,which is associated with prognosis and survival rate of patients.Alterations of mitochondrial dynamics influence the cancer progress and metastasis,but its mechanism is still unclear.