Hedgehog-Gli信号传导通路在脑肿瘤中的研究进展

 脑肿瘤，特别是恶性脑肿瘤的治疗目前仍是临床医生面临的一个难题，重要的原因之一是由于对脑肿瘤的发生发展机制尚不明了。最新研究表明：神经干细胞、脑肿瘤干细胞都可能参与这一过程，针对干细胞水平的研究将给脑肿瘤的治疗带来新希望。Hedgehog-Gli信号通路正是一条影响干细胞生物学行为的重要通路。本文就该通路在神经系统发育、神经干细胞分化和脑肿瘤发生的研究作一综述。

Hedgehog-Gli signalling pathway and its role in brain tumor initiation

Nowadays the therapy of malignant brain tumors is still a challenge to neurosurgeons.One of the most important reasons is the initial mechanisms of brain tumors have never been well illustrated.Recent studies demonstrate that neural stem cells and brain tumor stem cells are involved in the process of brain tumor development.It is believed that the researches focused on stem cells may bring new hope to the incurable disease.Hedgehog-Gli signalling pathway has an impact on biological behavior of stem cells.We reviewed the recent studies to summary its roles on embryonic development,stem cell differentiataion and brain tumor initiation.