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从阴火论治糖尿病下肢血管病变临床研究
引用本文:孙文东.从阴火论治糖尿病下肢血管病变临床研究[J].中医学报,2017,32(8).
作者姓名:孙文东
作者单位:鄢陵县中医院,河南鄢陵,461200
基金项目:河南省中医药科学研究专项课题
摘    要:目的:观察从阴火论治糖尿病下肢血管病变的临床疗效。方法:100例糖尿病下肢血管病变患者随机分为对照组和观察组各50例。对照组给予胰岛素皮下注射降低血糖、活血化瘀、扩张血管、营养神经治疗,治疗20 d后停用静脉给药,基础降低血糖治疗。观察组在对照组治疗基础上从阴火论治自拟方剂,日1剂,水煎服。两组患者均连续治疗3个月。比较两组患者临床疗效、中医证候积分、踝肱指数(ankle-brachial index,ABI)、心踝血管指数(cardio-ankle vascular index,CAVI)、C反应蛋白及胫前动脉内径。结果:观察组临床疗效优于对照组(P0.05)。两组患者ABI、CAVI、中医证候积分与治疗前比较,差异均有统计学意义(P0.05);观察组治疗后与对照组同期比较,差异均有统计学意义(P0.05)。两组患者治疗后C反应蛋白及胫前动脉内径与治疗前比较,差异均有统计学意义(P0.05);观察组治疗后与对照组同期比较,差异均有统计学意义(P0.05)。结论:从阴火论治糖尿病下肢血管病变疗效显著,可以升高ABI、CAVI,降低中医证候积分、C反应蛋白及胫前动脉内径。

关 键 词:糖尿病下肢血管病变  从阴火论治  踝肱指数  心踝血管指数  中医证候积分  C反应蛋白  胫前动脉内径  中西医结合

Clinical Study on Treatment of Diabetic Lower Extremity Vascular Disease from Yin Fire Theory
SUN Wendong.Clinical Study on Treatment of Diabetic Lower Extremity Vascular Disease from Yin Fire Theory[J].China Journal of Chinese Medicine,2017,32(8).
Authors:SUN Wendong
Abstract:Objective:To observe the clinical effect of the theory of Yin Fire in treating diabetes-related lower-extremity arterial disease.Methods:100 patients with lower-extremity arterial disease were randomly divided into the control group and the observation group,with each group consisting of 50 cases.The patients of the control group were given subcutaneous insulin injection to reduce blood glucose,as well as other therapies like promoting blood circulation and removing blood stasis,dilating blood vessels and neurotrophic therapy.The intravenous administration was stopped 20 days later and the patients were medicated with fundamental glucose-lowering treatment.As for patients of the observation group,based on the control group,they were medicated with self-prescribed therapy according to the theory of Yin Fire,once daily by decoction.Patients of the both groups were treated for 3 months consecutively.The clinical effects,TCM syndrome scores,ankle-brachial indexes (ABI),cardio-ankle vascular indexes (CAVI),C-reactive protein contents and pretibial artery diameter of patients of the two groups were compared.Results:The clinical effect of the observation group was better than that of the control group (P < 0.05).Compared with those before treatment,the ABI,CAVI,TCM syndrome score of patients of the two groups had great difference,which showed statistical significance (P < 0.05);the differences between the observation group and the control group after the treatment also had statistical significance (P < 0.05).The differences of the two groups in terms of C-reactive protein content and inner diameter of the tibial artery before and after treatment had statistical significance (P < 0.05);the differences between the two groups in such aspects after treatment also had statistical significance (P < 0.05).Conclusion:Treating the diabetes-related lower-extremity arterial disease based on the theory of Yin Fire has significant effects,and it can increase ABI and CAVI and decrease the TCM syndrome score,C-reactive protein content and the inner diameter of tibial artery.
Keywords:diabetic lower extremity vascular lesions  treatment from the Yin fire theory  ankle-brachial index  cardio-ankle vascular index  TCM syndrome  C reactive protein  pretibial artery diameter  combination of Chinese and Western medicine
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