沙棘糖浆联合枸橼酸莫沙必利片治疗儿童功能性消化不良的临床研究

目的 探讨沙棘糖浆联合枸橼酸莫沙必利片治疗儿童功能性消化不良的临床疗效。方法 选取功能性消化不良患儿为研究对象。对照组给予枸橼酸莫沙必利片，观察组给予口服沙棘糖浆，比较两组患儿治疗效果。结果 经治疗4周后，观察组的总有效率显著高于对照组。结论 沙棘糖浆联合莫沙必利可改善临床症状，其机制可能与提高血清NPY和LEP水平有关。

Clinical study of Hippophae rhamnoides syrup combined with mosapride citrate tablets in the treatment of functional dyspepsia in children

Abstract: Objective To investigate the clinical effect of Hippophae rhamnoides syrup combined with mosapride citrate tablets in the treatment of functional dyspepsia in children. Methods Eighty children with functional dyspepsia were randomly divided into control group and observation group. The control group was given Mosapride citrate tablets, and the observation group was given Hippophae rhamnoides syrup on the basis of the control group. The treatment course of the two groups was four weeks. The total effective rate of treatment between the two groups was compared. The clinical symptom scores of the two groups were compared. The changes of serum neuropeptide Y (NPY) and leptin (LEP) were compared between the two groups before and after treatment. Results After four weeks of treatment, the total effective rate in the observation group (97.5%) was significantly higher than that in the control group (85.0%). After treatment, the scores of postmeal fullness and discomfort, early satiety, upper abdominal pain and upper abdominal burning in the observation group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of NPY and LEP in the two groups were significantly higher than those before treatment, and the levels of serum NPY and LEP in the observation group were significantly higher than those in the control group (P < 0. 05). 05). No significant adverse reactions occurred in both groups. Conclusion Hippophae rhamnoides syrup combined with mosapride in the treatment of functional dyspepsia in children can significantly improve the clinical efficacy and clinical symptoms. The mechanism may be related to the increase of serum NPY and LEP levels.