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TLR2 was overexpressed independent of IL-6 in patients with valvular atrial fibrillation |
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| Authors: | Jian Wang Lei Xue Hailong Cao Fei Cui Ting Dai Yijiang Chen |
| Institution: | [1]Department of Thoracic and Cardiovascular Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China [2]Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu 210029, China. |
| Abstract: | Toll-like receptor 2 (TLR2) has recently been shown to be up-regulated in patients with non-valvular atrial fi-brillation (AF). The present study was aimed to determine whether the pathogenesis and development of AF is associated with the up-regulation of TLR2. Clinical data and right atrial appendage (RAA) specimens were col-lected from 20 patients with persisten AF (PeAF), 15 patients with paroxysmal AF (PaAF) and 13 patients with no history of AF undergoing valvular replacement. The results showed that g... |
| Keywords: | Toll-like receptor 2 atrial fibrillation inflammation valvular heart disease |
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