Inhibition of Cyclooxygenase and Thromboxane Synthetase on Oxygen Delivery and Utilization in Acute Respiratory Failure Canine

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Inhibition of Cyclooxygenase and Thromboxane Synthetase on Oxygen Delivery and Utilization in Acute Respiratory Failure Canine

The puapose of this study was to evaluate the effects of cyclooxygenase inhibitor (Ibuprofen)and thromboxane synthetase inhibitor (OKY-046) on oxygen metabolism in acute respiratory failure.Intratracheal instillation of hydrochloric acid was produced in 18 dogs, six dogs were pretreated with ibuprofen (IBU), six dogs with OKY-046 (OKY),and the remaindere used as control (CTR). After acid aspiration oxygen delivery (DO_2) fell in all groups as a results of decreased PaO_2 and cardiac output.However, oxygen consumption (VO_2)was maintained in all animals by the end of experiments except in CTR group. Arterial oxygen content maintained at baseline level throughout the experiments in IBU group. Meanwhile a significantly decreased mixed venous oxygen tension was found in OKY group after acid challenge. Liner regression of _vO_2 and DO_2 was confirmed in both CTR and OKY group. However,the dependent relationship between VO_2 and DO_2 was not identified in IBU group, which may indicate that the body oxygen metabolism was maintained rather well in acute rcspiratory failure dogs treated with ibuproten.