| Effects of Nerve Growth Factor on Bcl—2 Protein af—ter Spinal Cord Injury in Rats |
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| 引用本文： | 汤长华,曹晓建,王道新.Effects of Nerve Growth Factor on Bcl—2 Protein af—ter Spinal Cord Injury in Rats[J].南京医科大学学报(英文版),2002,16(3):112-114. |
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| 作者姓名： | 汤长华 曹晓建 王道新 |
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| 作者单位： | TANG Chang hua，CAO Xiao jian，WANG Dao xinDepartment of Orthopedics，the First Affiliated Hospital of NJMU，Nanjing 210029，P.R.China |
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| 基金项目： | NationalNaturalScienceFoundationof
China (3980 0 176 ) |
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| 摘 要： | Ａｐｏｐｔｏｓｉｓｉｓａｐｒｏｃｅｓｓｏｆｃｅｌｌ”ｓｕｉｃｉｄｅ”ｉｎｗｈｉｃｈｔｈｅｃｅｌｌａｃｔｉｖｅｌｙｋｉｌｌｓｉｔｓｅｌｆａｔａｐｈｙｓｉｏｌｏｇｉ ｃａｌｏｒｐａｔｈｏｌｏｇｉｃａｌｃｏｎｄｉｔｉｏｎｏｃｃｕｒｒｉｎｇｉｎｉｎｊｕｒｅｄｓｐｉｎａｌｃｏｒｄ .Ｔｏｅｘｐｌｏｒｅｔｈｅｐｒｏｔｅｃｔｉｖｅｍｅｃｈａｎｉｓｍｓｏｆｎｅｒｖｅｇｒｏｗｔｈｆａｃｔｏｒ(ＮＧＦ)ｏｎｉｎｊｕｒｅｄｓｐｉｎａｌｃｏｒｄ ,ｔｈｅｃｈａｎｇｅｓｏｆｔｈｅｂｃｌ 2ｐｒｏｔｅｉｎｗｅｒｅｍｅａ ｓｕｒｅｄｂ…
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| 关 键 词： | 脊髓损伤 神经生长因子 Bcl－2基因 动物实验 |
Effects of Nerve Growth Factor on Bcl-2 Protein after Spinal Cord Injury in Rats |
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| TANG Chang hua,CAO Xiao jian,WANG Dao xin.Effects of Nerve Growth Factor on Bcl-2 Protein after Spinal Cord Injury in Rats[J].Journal of Nanjing Medical University,2002,16(3):112-114. |
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| Authors: | TANG Chang hua CAO Xiao jian WANG Dao xin |
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| Institution: | Department of Orthopedics, the First Affiliated Hospital of NJMU, Nanjing 210029,P. R. China |
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| Abstract: | Objective To explore the protective mechanisms of nerve growth factor( NGF) ou spinal cord injury(SCI) and provide theoretical basis for its clinical application. MethodsThe SCI of Wistar rats was done by Allens weight dropping way by a 10 g × 2.5 cm impact on theposterior of spinal cord T8 NGF ( 3 g/L, 20d) or normal saline was injected to treatment group ratsthrough catheter into subarachnoid space at 0,2,4,8,12 and 24 h after SCI. The expression of bcl-2 protein levels in rat spinal cord was detected by immunohistoclemistry. Results The strong expres-sion sequence of bcl-2 protein was found in spinal cord of normal rat group. The levels of bcl-2 pro-tein after SCI in NGF treatment group increased more significantly than those in normal saline treatmentgroup (P＜0. 01). Conclusion NGF could protect injured spinal cord by stimulating bcl-2 pro-tein expression and suppressing apoptosis after SCI. |
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| Keywords: | nerve growth factor spinal cord injury bcl 2 apoptosis |
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