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Genotoxic and tumorigenic pyrrolizidine alkaloids in Chinese herbal plants
作者姓名:P.P.Fu  Q.xia  M.W.Chou  G.Lin
作者单位:[1]NationalCenterforToxicologicalResearch,Jefferson,AR72079,USA [2]DepartmentofPharmacology,theChineseUniversityofHongKong,Shatin,HongKong,SpecialAdministrativeRegion
基金项目:This article is not an official U.S. Food and Drug Administration guidance or policy statement. No official support or endorsement by the U.S. Food and DrugAdministration is intended or should be inferred.
摘    要:Pyrrolizidine alkaloids are a class of hepatotoxic and tumorigenic compounds detected in Chinese herbal plants, contaminated foods, and dietary supplements. In this review, the sources, toxicity, genotoxicity, tumorigenicity, and the metabolic pathways,particular the activation pathways leading to hepatotoxicity and tumorigenicity, of pyrrolizidine alkaloids are briefly discussed, with a focus on the most recent important findings concerning the genotoxic mechanism by which riddelliine liver tumors. This mechanism involves the formation of 6,7-dihydro-7-hydroxy-1-hydroxymethy1-5H-pyrrolizine (DHP)-derived DNA adducts and may be general to most carcinogenic pyrrolizidine alkaloids.

关 键 词:肿瘤发生  吡咯双烷类  生物碱  中草药  肝脏毒性

Genotoxic and tumorigenic pyrrolizidine alkaloids in Chinese herbal plants
P.P.Fu Q.xia M.W.Chou G.Lin.Genotoxic and tumorigenic pyrrolizidine alkaloids in Chinese herbal plants[J].Journal of Nanjing Medical University,2005,19(1):1-9.
Authors:PPFu  QXia  MWChou  GLin
Institution:1. National Center for Toxicological Research, Jefferson, AR 72079, USA
2. Department of Pharmacology, the Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region
Abstract:Pyrrolizidine alkaloids are a class of hepatotoxic and tumorigenic compounds detected in Chinese herbal plants, contaminated foods, and dietary supplements. In this review, the sources, toxicity, genotoxicity, tumorigenicity, and the metabolic pathways, particular the activation pathways leading to hepatotoxicity and tumorigenicity, of pyrrolizidine alkaloids are briefly discussed, with a focus on the most recent important findings concerning the genotoxic mechanism by which riddelliine liver tumors. This mechanism involves the formation of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts and may be general to most carcinogenic pyrrolizidine alkaloids.
Keywords:hepatotoxicity  tumorigenicity  pyrrolizidine alkaloids  Chinese herbal
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