| 胰腺癌预后的多因素分析 |
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| 引用本文： | 韩玥,南克俊,隋晨光,阮之平. 胰腺癌预后的多因素分析[J]. 南京医科大学学报(英文版), 2004, 18(3) |
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| 作者姓名： | 韩玥 南克俊 隋晨光 阮之平 |
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| 作者单位： | 1. 西安交通大学第一医院肝胆外科,西安,710061,中国
2. 西安交通大学第一医院肿瘤内科,西安,710061,中国 |
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| 摘 要： | 目的 :探讨影响胰腺癌的预后因素。方法 :对 113例病例资料完整的胰腺癌病例进行回顾性统计 ,应用COX比例风险模型对 9项指标进行了多因素分析 ,并用Kap lan Meier法计算其生存率。结果 :本组生存期 0 .1～ 82 .0个月 ,中位生存期 3.0个月。 6、12、18、36月的生存率分别为35 6 %、2 0 3%、15 9%、6 2 %。多变量分析显示 ,影响胰腺癌预后最明显的因素是黄疸、转移、治疗方式以及是否行综合治疗。结论 :胰腺癌预后由多种因素决定 ,伴有黄疸、转移的的胰腺癌病人预后差 ,行根治性切除术、综合治疗可改善预后。
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| 关 键 词： | 胰腺癌 Cox’s比例风险模型 预后 |
Prognostic Factors in Patients with Pancreatic Carcinoma |
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| HAN Yue,NAN Ke-jun ,SUI Cheng-guang ,RUAN Zhi-ping. Prognostic Factors in Patients with Pancreatic Carcinoma[J]. Journal of Nanjing Medical University, 2004, 18(3) |
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| Authors: | HAN Yue NAN Ke-jun SUI Cheng-guang RUAN Zhi-ping |
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| Affiliation: | HAN Yue,NAN Ke-jun 1,SUI Cheng-guang 1,RUAN Zhi-ping 1 Department of Hepatobiliary Surgery,1Department of Oncology,the First Hospital of Xi'an Jiaotong University,Xi'an 710061,P.R.China |
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| Abstract: | Objective: To evaluate the major prognostic factors in patients with pancreatic carcinoma. Methods:113 cases of a particular disease were retrospectively analysed and 9 factors for prognosis were studied by multivaritate analysis with Cox proportional hazards survival model.Survival rate was calculated by Kaplan-Meier estimation. Results:In this group,survival time was 0.1 to 82 months,and the median survival time was 3 months.Overall survival rates at month 6,12,18,36 were 35.6%,20.3%,15.9% and 6.2%,respectively.Multivariate analyses revealed significant prognostic factors as follows:jaundice,metastasis,therapy method and synthetic therapy. Conclusion: The prognosis of pancreatic carcinoma is determined by various factors.Jaundice and metastasis are independent predictors of poor survival.Radical operation and synthetic therapy will improve the prognosis. |
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| Keywords: | pancreatic carcinoma Cox proportional hazards model prognosis |
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