| 改良法制作SD大鼠局灶性脑缺血/再灌注模型探讨 |
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| 引用本文： | 李向荣,韩江全,何敏.改良法制作SD大鼠局灶性脑缺血/再灌注模型探讨[J].遵义医学院学报,2008,31(5). |
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| 作者姓名： | 李向荣 韩江全 何敏 |
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| 作者单位： | 遵义医学院第五附属医院,神经内科,广东,珠海,519100 |
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| 基金项目： | 珠海市科学技术局资助课题[编号 PC20041029]珠海市医学重点学科建设资助项目
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| 摘 要： | 目的探讨线栓法制造大鼠局灶性脑缺血/再灌注模型的成功经验。方法采用改良线栓法制作Sprague-Dawley(SD)大鼠大脑中动脉阻塞(MCAO)局灶性脑缺血/再灌注动物模型。结果30只大鼠中,经神经功能评分、核磁共振血管成像及TTC染色验证,28只造模成功,成功率超过90%。结论改良线栓法MCAO制作大鼠局灶性脑缺血/再灌注模型值得推广。
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| 关 键 词： | SD大鼠 脑缺血 模型制作 |
Research on middle cerebral artery occlusion(MCAO) models in SD rats |
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| LI Xiang-rong,HAN Jiang-quan,HE Min.Research on middle cerebral artery occlusion(MCAO) models in SD rats[J].Acta Academiae Medicine Zunyi,2008,31(5). |
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| Authors: | LI Xiang-rong HAN Jiang-quan HE Min |
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| Institution: | LI Xiang-rong,HAN Jiang-quan,HE Min(The fifth Affiliated Hospital of Zunyi Medical College,Guangdong ZhuHai 519100,China) |
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| Abstract: | Objective To probe the experience of suture methods for rats model of focal cerebral ischemia/reperfusion.Methods The middle cerebral artery occlusion and Focal cerebral ischemia/reperfusion model was made by reforming suture method in Sprague-Dawley(SD) rats.Results Of all the 30 SD rats for model building,28 were made successfully.The achievement ratio was over 90%.Conclusions The modified MCAO method of focal cerebral ischemia/reperfusion by suture in rats and the skills were worth to be spread. |
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| Keywords: | SD rats cerebral ischemia/reperfusion model building |
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