乙肝表面抗原阳性孕妇肌注乙肝免疫球蛋白预防母婴传播52例分析

①目的　探讨经母体对胎儿行被动免疫在预防乙型肝炎病毒 (HBV)宫内感染中的作用。②方法　对自孕 2 0周起多次肌注乙肝免疫球蛋白 (HBIG)的HBsAg(+)孕妇 52例 (A组 )及未注射的 32例HBsAg(+)孕妇 (B组 ) ,用固相放免法和套式PCR检测母血HBsAg、HBV -DNA及新生儿血HBsAg、抗HBs、HBV -DNA。③结果　A组 52例新生儿中 48例血清抗HBs(+) ,与B组相比具有显著差异 (P <0 .0 5)。A组新生儿血HBsAg、HBV -DNA检出率均明显低于B组。A组孕妇用药后血HBsAg滴度及HBV -DNA水平较用药前明显降低。④结论　经母体对胎儿行被动免疫可有效的预防HBV宫内感染

The prventive effect of HBIG injection in 52 pregnant women with HBsAg on HBV transmission from mother to infant

Objective To investigate the effect of passive immunization of fetus by injection of mother with HBIG on prevention of HBV intrauterine infection. Methods Eighty-four pregnant women with HBsAg positive were divided into two groups: group A (52 cases) were injected with HBIG during pregnancy; proup B (32 cases) were followed up without injection of HBIG as controls. The blood samples of mothers and their infants were tested with radioimmunosassay and PCR. Results Of 53 infants in group A, 48(90.56%) were positive for anti-HBs, but 2 infants in-group B (15.63%) were positive for anti-HBs (P<0.05). The infants with HBsAg positive and HBVDNA positive in group A were fewer than those in group B (P<0.05). Passive immunization of fetus by injection to mother with HBsAg may prevent HBV intrauterine infection effectively.