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术后疼痛与镇痛对患者免疫功能的影响
引用本文:许立国,赵琳.术后疼痛与镇痛对患者免疫功能的影响[J].实用疼痛学杂志,2005,1(4):228-230.
作者姓名:许立国  赵琳
作者单位:山东省淄博市第三人民医院麻醉科,255029
摘    要:目的 观察术后疼痛与镇痛对患者IgA、IgG、IgM三种免疫球蛋白的影响。方法 选择ASAⅠ~Ⅱ级妇科择期子宫全切除术患者60例,随机分为A、B两组,每组30冽,两组患者皆常规采用硬膜外麻醉,选L1-2或T12-L1间隙,用药1.73%碳酸利多卡因。A组术毕不用术后镇痛,疼痛发作难忍时,先采血后再用哌替啶50mg肌注镇痛;B组术毕保留硬膜外导管接持续止痛泵。两组患者皆定时经肘部静脉采血做免疫球蛋白测定,记录并计算均值。结果 A组与正常值比较,血清中三种免疫球蛋白呈明显升高趋势(P〈0.05),A组与B组同时间段比较,三种免疫球蛋白亦呈明显升高趋势(P〈0.05),B组与正常血清免疫球蛋白比较差异无统计学意义(P〉0.05)。结论 术后镇痛对于稳定患者免疫功能有重要作用。

关 键 词:疼痛,手术后  镇痛  免疫球蛋白  术后镇痛  术后疼痛  免疫功能  患者  免疫球蛋白测定  血清免疫球蛋白  73%碳酸利多卡因
收稿时间:2004-12-16
修稿时间:2004年12月16

Influence of postoperative pain and analgesia on patient's immunological function
XU Li-guo,ZHAO Lin.Influence of postoperative pain and analgesia on patient''''s immunological function[J].Pain Clinic Journal,2005,1(4):228-230.
Authors:XU Li-guo  ZHAO Lin
Abstract:Objective To observe the postoperative pain and analgesia effect on immunoglobulin (IgA, IgG, IgM) in patients with hysterectomy. Methods Sixty patients ASA physical status I -II scheduled abdominal hysterectomy under epidual block were randomly assigned to two groups, control group (group A, n=30)and postoperative analgesia group (group B, n=30). 1.73% lidocaine carbonate was used for anesthesia in both group. The continuous epidural analgesia (CEA) pump was used in group B after the operation, while pethidine was injected on call in group A. To estimate immunoglobulin(IgA, IgG, IgM), the venous blood was collected before anesthesia and at 4, 8, 12, 16, 20, 24 th postoperatively. Results There was no significant difference in two groups regarding all above indexes before anesthesia (P>0.05). Compared with the normal indexes, the IgA, IgG and IgM were increased significantly after operaton in group A (P<0.05), but no sistatistic difference in group B (P>0.05). Conclusion Postoperative analgesia can stabilize immunological function in patient with hysterectomy.
Keywords:Pain  Postoperative  Analgesia  Immunoglobulins
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