首页 | 本学科首页   官方微博 | 高级检索  
检索        

EMD_(56431)对高血压大鼠的降压作用
引用本文:向菲,刘东,马世玉,胡本容,姚伟星,辛建保.EMD_(56431)对高血压大鼠的降压作用[J].华中科技大学学报(医学版),2003(2).
作者姓名:向菲  刘东  马世玉  胡本容  姚伟星  辛建保
作者单位:华中科技大学同济医学院附属协和医院呼吸内科 武汉430022 (向菲),华中科技大学同济医学院基础医学院药理学系 武汉430030 (刘东,马世玉,胡本容,姚伟星),华中科技大学同济医学院附属协和医院呼吸内科 武汉430022(辛建保)
摘    要:目的 探讨 ATP敏感钾通道 (KATP)开放剂 EMD56 431 对清醒自发性高血压大鼠 (SHR)和肾性高血压大鼠(RHR)血压的影响。方法 采用静脉注射和灌胃给药的方式 ,经颈总动脉插管 ,动态监测动脉收缩压 (SAP) ,舒张压(DAP)及心率 (HR)的变化。并测定小鼠灌胃给予 EMD56 431 时的半数致死剂量 (L D50 )。结果 静注或灌胃给予 EMD56 4312 5、 5 0、 10 0 μg/ kg均可使 SHR血压产生剂量依赖性的下降 ,同时反射性加快 HR。前者降压维持时间分别为 4 5 min、6 h和 6 h以上 ,后者可分别维持 4 5 m in、 1h和 6 h以上。静注和灌胃 EMD56 431 产生的效应相当。灌胃 EMD56 431 亦可使RHR血压产生剂量依赖性的下降 ,降压维持时间分别为 30 m in、 4 5 min和 6 h以上。小鼠 L D50 为 8.5 4 mg/ kg,95 %可信区限为 7.87~ 9.93mg/ kg。结论  EMD56 431 对 SHR和 RHR有显著而持久的降压作用 ,安全有效 ,且该药生物利用度较高 ,具有广阔的临床开发前景

关 键 词:EMD56431  自发性高血压  肾性高血压  抗高血压药

Effects of EMD_(56431) on Blood Pressure in Hypertensive Rats
Xiang Fei,Liu Dong,Ma Shiyu et al.Effects of EMD_(56431) on Blood Pressure in Hypertensive Rats[J].Journal of Huazhong University of Science and Technology(Health Sciences),2003(2).
Authors:Xiang Fei  Liu Dong  Ma Shiyu
Institution:Xiang Fei,Liu Dong,Ma Shiyu et al 1 Department of Respiratory Medicine,Xiehe Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022 2 Department of Pharmacology,School of Basic Medical Sciences,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030
Abstract:Objective To study the effects of a novel potassium channel activator, EMD 56431 on blood pressure in spontaneously hypertensive rat (SHR) and renal hypertensive rat (RHR). Methods The different doses of EMD 56431 were administrated by injection into vein (i.v.) or intragastric irrigation (i.g.), to monitor the changes of systolic blood pressure (SAP), diastolic blood pressure (DAP) and mean arterial pressure (MAP) by cannulation in common carotid artery. The medial lethal dose (LD 50 ) in mice by i.g. EMD 56431 was calculated. Results Administation of EMD 56431 (25, 50, 100 g/kg, i.v. or i.g.) could produce hypotensive effects in a dose dependent manner and reflexly increase heart rates (HR) of SHR. The persisting duration of i.v. EMD 56431 was 45 min, 6 h, and over 6 h, and the duration was 45 min, 1 h, and over 6 h by i.g. EMD 56431 . Both of i.v. and i.g. EMD 56431 had comparable potency. The range of LD 50 was 7.87 to 9.93 mg/kg in mice. Conclusion EMD 56431 can markedly and continuously decrease the blood pressure in RHR and SHR. EMD 56431 is safe and effective and has a high bioavailability.
Keywords:EMD 56431  spontaneous hypertension  renal hypertenson  antihypertensive drug
本文献已被 CNKI 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号