C-erbB-2 ,nm23 蛋白表达与结直肠癌浸润转移的相关性

目的　探讨癌基因C- erbB- 2及转移抑制基因nm23在结直肠癌组织中的表达, 及其与局部浸润、淋巴结转移的关系。方法　采用免疫组化SP法, 检测66 例原发性结直肠癌患者手术切除的癌组织中C- erbB -2 及nm23 蛋白的表达。结果　C- erbB -2 蛋白阳性表达率与结直肠癌组织的分化程度无明显相关性(P>0 05), 与浸润深度、淋巴结的转移呈正相关( P<0. 05, P<0 .01)。nm23 蛋白在结直肠癌无淋巴结转移组中的阳性表达率显著高于有转移组(P<0. 01) , 其阳性表达率与结直肠癌淋巴结转移呈负相关。而且, 在淋巴结转移组中C -erbB -2 蛋白的阳性表达率与nm23 蛋白呈负相关。结论　C- erbB- 2 及nm23 蛋白的异常表达在结直肠癌的发生、发展和淋巴结转移中可能起重要作用。

Correlation between the Expression of C-erbB-2,nm23 Protein and Invasion, Lymph Node Metastasis of Human Colorectal Carcinoma

Objective To explore the relationship between the expressions of C-erbB-2,nm23 protein and local invasion,lymph node metastasis of colorectal carcinoma.Methods Using immunohistochemical technique SP method,the expression of C-erbB-2,nm23 protein was detected in 66 patients with human colorectal carcinoma.Results The positive expression rate of C-erbB-2 protein in colorectal carcinoma was not correlated with histological grade (P>0.05). There was a significant relationship between the expression of C-erbB-2 and the infiltrative depth,lymph node metastasis (P<0.05,P<0.01). The positive expression rate of nm23 protein was significantly higher in the group without lymph node metastasis than in the group with lymph node metastasis (P<0.01). The negative correlation was found between the nm23 expression and lymph node metastasis of colorectal carcinoma. Furthermore,the negative correlation of the positive expression was found between C-erbB-2 protein and nm23 protein in the group with lymph node metastasis.Conclusion The abnormal expression of C-erbB-2,nm23 protein has an important significance in development and lymph node metastasis of colorectal carcinoma.