| 3H－1，2－二氢－1－吡咯里嗪酮衍生物的合成 |
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| 引用本文： | 刘向莉,张守芳.3H－1，2－二氢－1－吡咯里嗪酮衍生物的合成[J].华中科技大学学报(医学版),1996(4). |
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| 作者姓名： | 刘向莉 张守芳 |
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| 作者单位： | 武汉同济医科大学药学院药物化学教研室，沈阳药科大学基础部有机化学研究室 |
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| 摘 要： | 实验证实３Ｈ－１，２二氢－１－吡咯里嗪酮（Ａ）及５－（４－氯苯甲酰基）３Ｈ－１，２－二氢－１－吡咯里嗪酮（Ｂ）具有明显的抗炎镇痛作用。在此基础上，设计合成了Ａ的１２个Ｍａｎｎｉｃｈ碱衍生物Ｃ（１－１２）及Ｂ的缩氨脲Ｄ１和肟Ｄ２，这１４个化合物均未见文献报道。药理实验证明，这些化合物大多具有抗炎镇痛活性，其中化合物Ｃ１、Ｃ２、Ｃ３、Ｃ９活性最为显著。
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| 关 键 词： | 二氢吡咯里嗪酮，Mannich碱，抗炎镇痛，合成 |
Synthesis of 3H-1,2-Dihydro-1-Pyrrolizinone Derivatives |
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| Liu Xiangli,Zhang Shoufang.Synthesis of 3H-1,2-Dihydro-1-Pyrrolizinone Derivatives[J].Journal of Huazhong University of Science and Technology(Health Sciences),1996(4). |
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| Authors: | Liu Xiangli Zhang Shoufang |
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| Abstract: | H-1, 2-Dihydro-1-pyrrolizinone and 5-(4-Chlorobenzoyl) 3H-1,2 -dihydro-1-pyrrolizinone were found to have significant anti-inflammatory and analgesic action, Fourteen 1-pyrrolizinone derivatives were synthesized which had not been reported in the literature ever before. Pharmacological tests showed that most of them had remarkable anti-inflammatory and analgesic activities. |
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| Keywords: | dihydro-1-pyrrolizinone mannich base anti-inflammation analgesic synthesis |
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