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单用托特罗定与联合萘哌地尔治疗女性膀胱过度活动症的疗效比较
引用本文:揭红,郑新民,严春晖,朱亮.单用托特罗定与联合萘哌地尔治疗女性膀胱过度活动症的疗效比较[J].武汉大学学报(医学版),2009,30(4).
作者姓名:揭红  郑新民  严春晖  朱亮
作者单位:1. 武汉市儿童医院,湖北武汉,430016
2. 武汉大学中南医院泌尿外科,湖北,武汉,430071
3. 解放军161医院泌尿外科,湖北,武汉,430010
摘    要:目的:比较托特罗定联合萘哌地尔与单用托特罗定治疗女性膀胱过度活动症的疗效。方法:将35例女性膀胱过度活动症患者随机分为托特罗定联合萘哌地尔治疗组(18例)与单用托特罗定治疗组(17例),治疗时间为4周,以平均24 h排尿次数、平均24 h尿失禁次数、初始尿意容量(FDV)、最大膀胱压容量(MCBC)、最大尿流率(Qmax)为疗效指标,比较两组疗效。结果:2组间比较治疗前后24 h排尿次数、平均24 h尿失禁次数、初始尿意容量(FDV)、最大膀胱压容量(MCBC)、最大尿流率(Qmax),差异有显著性(P<0.05),联合用药组的上述指标的改善程度明显优于单独用药组。结论:托特罗定联合萘哌地尔治疗女性膀胱过度活动症的疗效优于单用托特罗定。

关 键 词:膀胱过度活动症  托特罗定  萘哌地尔  药物治疗

Comparison of Effect Between the Treatment of Tolterodine Combined with Naftopidil and of Tolterodine Alone on Female Overactive Bladder
JIE Hong,ZHENG Xinmin,YAN Chunhui,ZHU Liang.Comparison of Effect Between the Treatment of Tolterodine Combined with Naftopidil and of Tolterodine Alone on Female Overactive Bladder[J].Medical Journal of Wuhan University,2009,30(4).
Authors:JIE Hong  ZHENG Xinmin  YAN Chunhui  ZHU Liang
Institution:JIE Hong1,ZHENG Xinmin1,YAN Chunhui2,ZHU Liang21 Dept.of Urology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China2 Dept.of Urology,No.161 Hospital of PLA,Wuhan 430010,China
Abstract:Objective: To compare the the clinical effect of tolterodine combined with naftopidil and that of tolterodine alone for female overactive bladder(OAB).Methods: Thirty-five female patients with OAB were randomly divided into tolterodine plus naftopidil treatment group A(group A,n=18) and tolterodine alone treatment group(group B,n=17).The effects were evaluated with urodynamic data including frequency of micturiation and incontinence,maximum flow rate(Qmax),first desire to void(FDV),and maximum cystometric c...
Keywords:Overactive Bladder  Tolterodine  Naftopidil  Pharmacotherapy  
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