| 大剂量病毒唑治疗流行性出血热对肝脏影响的研究 |
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| 引用本文： | 王启南,桂希恩,杨自成,彭万先,赵红卫,彭竹山,王慧玲,姜有枝,吴辉,JM Meegan,JW Huggins,T Cosgriff,JI Smith.大剂量病毒唑治疗流行性出血热对肝脏影响的研究[J].武汉大学学报(医学版),1988(4). |
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| 作者姓名： | 王启南 桂希恩 杨自成 彭万先 赵红卫 彭竹山 王慧玲 姜有枝 吴辉 JM Meegan JW Huggins T Cosgriff JI Smith |
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| 作者单位： | 河北医学院附二医院传染病学教研室，河北医学院附二医院传染病学教研室，河北医学院附二医院传染病学教研室，河北医学院附二医院传染病学教研室，河北医学院附二医院传染病学教研室，河北医学院附二医院传染病学教研室，河北医学院附二医院传染病学教研室，河北医学院附二医院传染病学教研室，河北医学院附二医院传染病学教研室，美国军事医科院传染病研究所，美国军事医科院传染病研究所，美国军事医科院传染病研究所，美国军事医科院传染病研究所 |
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| 摘 要： | 采用双盲法,大剂量病毒唑(345mg/kg)治疗 EHF 的同时,观察了用药组126例与安慰剂组118例,各病期肝脏功能损害情况,血清 GPT 及 GOT活性升高,总蛋白及白蛋白含量明显下降,两组间差异无显著性(P>0.05)。说明 EHF 患者肝实质细胞的损害较普通,应用病毒唑后,不会加重肝脏的损害。
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| 关 键 词： | 出血热 流行性/药物疗法 三氮唑核苷/药效学 天门冬氨酸基转移酶/生物合成 丙氨酸转氨酶类/生物合成 |
Double-Blind Clinical Evaluation of EHF Patients' Liver Function Test Treated with High-Dose Intravenous Ribavirin |
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| Wang Chilang.Double-Blind Clinical Evaluation of EHF Patients'''' Liver Function Test Treated with High-Dose Intravenous Ribavirin[J].Medical Journal of Wuhan University,1988(4). |
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| Authors: | Wang Chilang |
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| Abstract: | 244 patients treated with high-dose intravenous ribavirin(126cases)and placedo(118cases)were prospectively studied in the double-blind clinical trial. In the study,we compared results of liver function test(LFT)between two group EHF patients.Almost all of patients had abnormal LFT results including increased activity of sGPT,sGOT and lowered level of serum total protein and albumin.To placebo-treated patients,LFT results seemed worse than those of ribavirin-treated patients but there was no significant difference between two group patients' LFT(P>0.05).We conclude that high-dose intravenous ribavirin therapy(345mg/kg/d)is safe to the livers of EHF patients'.For many patients to have abnormal LFT results during entire illness period is because of the discase itself but not of ribavirin's toxic side effects. |
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| Keywords: | hemorrhagic fever epidemic/DT ribavirin/PD aspartate aminotransferase/BI alanine aminotransferase/BI |
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