| Toll样受体与HIV-1病毒感染 |
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| 引用本文： | 孙黎.Toll样受体与HIV-1病毒感染[J].武汉大学学报(医学版),2010,31(6). |
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| 作者姓名： | 孙黎 |
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| 作者单位： | 武汉大学医学病毒研究所/病毒学国家重点实验室,湖北,武汉,430071 |
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| 基金项目： | 国家自然科学基金资助项目，中央高校基本科研业务费专项基金 |
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| 摘 要： | 感染人类免疫缺陷病毒(HIV)后,引起免疫系统的持续激活,进而导致CD4+T细胞数目不断减少,最终导致人类免疫缺陷综合征(AIDS)的发生。阻断免疫系统的持续激活,可能是减缓AIDS发展进程的重要途径。有研究表明,Toll样受体(TLR)与HIV感染后免疫系统的持续激活密切相关。同时,TLR是重要的模式识别受体,在抗微生物的非特异性免疫中发挥重要作用并参与调节特异性免疫。本文综述了TLR与HIV-1的关系,以给HIV-1治疗及疫苗的研究提供参考。
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| 关 键 词： | 人类免疫缺陷症毒-1 Toll样受体 |
Toll Like Receptors and HIV-1 Infection |
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| SUN Li.Toll Like Receptors and HIV-1 Infection[J].Medical Journal of Wuhan University,2010,31(6). |
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| Authors: | SUN Li |
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| Abstract: | HIV infection lead to persistent immune system activation,as well as subsequent CD4+ Tcell depletion and progression to AIDS.Blocked the persistent immune system activation may be an important way to slow down the progression to AIDS.Several study groups provided evidence that TLRs had closely association between immune system activation after HIV infection.Furthermore,TLRs which play a significant role in innate immunity and take part in adaptive system are an important pattern recognition receptor.We believe this context which summarizes the relationship between TLRs and HIV-1could supply consultation to the therapy of HIV-1. |
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| Keywords: | HIV-1 Toll Like Receptors |
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