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复发性生殖器疱疹患者黏附分子ICAM-1、L-选择素和P-选择素的表达
引用本文:季卉,李富荣,童秋生,房思宁,杜晓红,魏丽虹,王新根.复发性生殖器疱疹患者黏附分子ICAM-1、L-选择素和P-选择素的表达[J].广东医学,2002,23(4):367-369.
作者姓名:季卉  李富荣  童秋生  房思宁  杜晓红  魏丽虹  王新根
作者单位:1. 暨南大学医学院第二附属医院,广东省深圳市人民医院皮肤性病科
2. 暨南大学医学院第二附属医院,广东省深圳市人民医院临床医学研究中心,518020
摘    要:目的 探讨ICAM-1、L-选择素及P-选择素在复发性生殖器疱疹(RGH)患者发作期和静止期的变化规律及相关性。方法 用免疫荧光染色法及流式细胞术分析了19例发作期和16例静止期RGH患者外周血黏附分子ICAM-1,L-选择素及P-选择素表达情况。结果 RGH患者发作期外周血淋巴细胞ICAM-1表达显著高于RGH静止期患者及正常对照组(P<0.01),淋巴细胞表达的L-选择素及血小板表达的P-选择素在RGH患者发作期、静止期及正常对照组之间差异无显著性(P>0.05),外周血淋巴细胞ICAM-1的表达与RGH患者年复发次数有明显的相关性(P<0.05)。结论 RGH患者外周血淋巴细胞ICAM-1的表达水平可作为判断RGH复发及病情严重程度的参考指标。

关 键 词:复发性生殖器疱疹  黏附分子  流式细胞术  ICAM-1  L-选择素  P-选择素
修稿时间:2001年12月4日

Expression of adhesion molecules in patients with recurrent genital herpes
Ji Hui,Li Furong,Tong Qiusheng,et al..Expression of adhesion molecules in patients with recurrent genital herpes[J].Guangdong Medical Journal,2002,23(4):367-369.
Authors:Ji Hui  Li Furong  Tong Qiusheng  
Institution:Ji Hui,Li Furong,Tong Qiusheng,et al. Department of Dermatology,Shenzhen People's Hospital,Shenzhen 518020
Abstract:Objective To study the expression of ICAM-1,L-selectin and P-selectin in lymphocytes and platelets from patient with recurrent genital herpes (RGH). Methods Adhseion molecules ICAM-1,L-selectin and P-selectin were investigated in 19 active RGH and 16 in inactive RGH patients by using flow cytometric analysis and immunofluorescence staining method. Results Expression of ICAM-1 in lymphocytes from active stage RGH was significant higher than that of inactive RGH and control ( P < 0.01 ). Expression of L-selectin in lymphocytes and P-selectin in platelets from active stage and inactive stage RGH patients were not significantly different compared with normal control( P >0.05). In addition , the recurrence times of RGH were significantly correlated with expression ICAM-1 in RGH patient ( P < 0.05 ). Conclusion Expression of ICAM-1 in lymphocytes from active RGH increases. It is important to have further study on the pathogenic significance of ICAM-1 in RGH.
Keywords:Recurrent genital herpes  Adhesion molecules  Flow cytometric
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