| 食管鳞状细胞癌组织中FAK和paxillin的表达 |
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| 引用本文： | 赵志华,庞霞,李晟磊,赵阿红,张红新,高冬玲.食管鳞状细胞癌组织中FAK和paxillin的表达[J].广东医学,2010,31(8). |
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| 作者姓名： | 赵志华 庞霞 李晟磊 赵阿红 张红新 高冬玲 |
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| 作者单位： | 郑州大学第一附属医院病理科、河南省肿瘤病理学重点实验室,郑州,450052 |
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| 摘 要： | 目的探讨FAK和桩蛋白(paxillin)在食管鳞状细胞癌(ESCC)组织中的表达及其意义。方法应用免疫组化SP法检测59例ESCC、27例癌旁不典型增生组织及36例正常食管黏膜组织中FAK和paxillin的表达。结果ESCC、癌旁不典型增生组织及正常黏膜组织中FAK的阳性表达率依次降低,分别为79.7%(47/59)、59.2%(16/27)和19.4%(7/36),组间比较差异有统计学意义(P0.05);ESCC、癌旁不典型增生组织及正常黏膜组织中paxillin的阳性表达率亦依次降低,分别为71.2%(42/59)、55.6%(15/27)和36.1%(13/36),组间比较差异有统计学意义(P0.05);FAK和paxillin表达均与ESCC的分化程度、浸润深度和淋巴结转移密切相关(P0.05)。ESCC组织中FAK与paxillin呈正相关关系(r=0.442,P0.05)。结论FAK和paxillin表达与ESCC的发生、发展和转移密切相关,联合检测FAK及paxillin可望成为ESCC早期诊断和预后判断的生物学标记之一,同时也将为治疗提供了新的靶点。
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| 关 键 词： | 食管 鳞状细胞癌 浸润 转移 |
Expressions of FAK and paxillin proteins in esophageal squamous cell carcinoma |
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| ZHAO Zhi-hua,PANG Xia,LI Sheng-lei,ZHAO A-hong,ZHANG Hong-xin,GAO Dong-ling.Expressions of FAK and paxillin proteins in esophageal squamous cell carcinoma[J].Guangdong Medical Journal,2010,31(8). |
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| Authors: | ZHAO Zhi-hua PANG Xia LI Sheng-lei ZHAO A-hong ZHANG Hong-xin GAO Dong-ling |
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| Institution: | ZHAO Zhi-hua,PANG Xia,LI Sheng-lei,ZHAO A-hong,ZHANG Hong-xin,GAO Dong-ling Department of Pathology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,China |
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| Abstract: | Objective To explore the expressions of FAK and paxillin proteins in esophageal squamous cell carcinoma (ESCC). Methods Immunohistochemical SP method was used to detect the expressions of FAk and paxillin proteins in 59 specimens of ESCC tissue,27 specimens of carcinoma adjacent atypical hyperplasia epithelium and 36 specimens of normal esophageal epithelium. Results The expression rates of FAK protein in carcinoma,adjacent atypical hyperplasia epithelium and normal esophageal epithelium specimens were 79.7... |
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| Keywords: | FAK paxillin |
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