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瘢痕疙瘩不同部位Bcl-2的表达及其意义
引用本文:张刚,罗少军,汤少明,梁杰,左强.瘢痕疙瘩不同部位Bcl-2的表达及其意义[J].广东医学,2006,27(12):1811-1812.
作者姓名:张刚  罗少军  汤少明  梁杰  左强
作者单位:广东医学院附属医院整形外科研究所,广东,湛江,524001
基金项目:国家自然科学基金;广东省自然科学基金
摘    要:目的分析瘢痕疙瘩浸润部、增生部和老化部凋亡蛋白Bcl-2表达差异以探讨瘢痕疙瘩呈浸润性生长的机制。方法取手术切除的瘢痕疙瘩组织反正常皮肤各12例为标本,对12例瘢痕疙瘩组织和正常皮肤行白细胞介素2免疫组织化学染色,比较瘢痕疙瘩不同病理部位和正常皮肤Bcl-2差异。结果瘢痕疙瘩浸润部Bcl-2明显高于增生部、老化部和正常皮肤,差异有显著性(q=4.29,P〈0.05),瘢痕疙瘩增生部Bcl-2明显高于老化部和正常皮肤,差异有显著性(q=4.20,P〈0.05),而后两者间差异无显著性(P〉0.05)。结论瘢痕疙瘩不同部位Bcl-2的表达差异可能是导致瘢痕疙瘩呈浸润性生长的机制之一。

关 键 词:瘢痕疙瘩  白细胞介素2  细胞凋亡
收稿时间:2006-07-02
修稿时间:2006年7月2日

Expression and significance of Bcl-2 in different part of keloid
ZHANG Gang , LUO Shao - jun , TANC shao-ming ,et al..Expression and significance of Bcl-2 in different part of keloid[J].Guangdong Medical Journal,2006,27(12):1811-1812.
Authors:ZHANG Gang  LUO Shao - jun  TANC shao-ming  
Institution:The Institute of Plastic Surgery in Guangdong Medical College, Zhanjiang 524001, China
Abstract:Objective To explore the aggressive growth characteristics in invasive,proliferative and aged parts of keloid by analysing the Bcl-2 index.Methods Fibroblasts of 12 keloids cases and 12 normal skin cases were investigated by immunohistochemical analysis of Bcl-2.Bcl2 index of difference parts in keloids and normal skin were compared.Results The Bcl-2 index of invasive parts of keloids was higher than those of proliferative and aged parts of keloid and normal skin(q=4.29,P<0.05).The Bcl-2 index of proliferative parts in keloids was higher than those of aged parts of keloid and normal skin((q=4.20),P<0.05).However there was no siginficant deference between the aged parts of keloid and the normal skin.Conclusion The difference in distribution of Bcl-2 indes may be responsible for the aggressive growth of keloid.
Keywords:Keloid B - cell lymphoma/leukemia- 2 Apoptosis
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