广东省城市成人脂肪性肝病患病率调查

目的脂肪性肝病与遗传、环境密切相关,广东省城市地区有其独特的经济文化特点,调查广东省城镇成人脂肪性肝病的患病率及其主要危险因素。方法用多阶段分层随机整群抽样方法,选择广东省内3个城镇,对18岁以上整体城镇人群进行问卷调查、体格检查、血生化和肝脏超声检查。结果广东省城镇成人(18岁及以上)脂肪性肝病患病率为23.6%(344/1458),男、女性脂肪性肝病患病率分别为24.9%和22.8%,差异无统计学意义(P=0.502)。酒精性脂肪性肝病患病率为1.1%,疑似酒精性脂肪性肝病患病率为2.1%,非酒精性脂肪性肝病患病率为20.4%。脂肪性肝病患病率随年龄增长而增加,50~60岁患病率最高(30.6%);多因素Lo-gistic回归分析显示男性、文化程度低、高血压、肥胖、腰臀比、腰围以及血液甘油三酯和血糖升高是广东省城镇人群成人脂肪性肝病的危险因素。结论广东省城镇人群成人脂肪性肝病患病率较高,以非酒精性为主,肥胖及其相关的多元代谢紊乱与脂肪性肝病的关系密切。

Epidemiological survey of prevalence of fatty liver in a general adult population in urban area of Guangdong Province

Objective Fatty liver disease (FLD) is related closely with gene and circumstance, Guangdong province has its own specialist in china, To determine prevalence of FLD and risk factors of nonalcoholic fatty liver disease (NAFLD) in urban area of Guangdong province.Methods A cross-sectional survey with randomized multistage stratified cluster sampling of inhabitants over 18 years old in 3 urban areas of Guangdong province was performed. Questionnaires, anthropometric measurements, biochemical tests and abdominal ultrasonography were carried out. Results Among 1 458 subjects,344 (23.6%) were diagnosed as having FLD (male 24.9%, female 22.8%, P=0.502), among which, the prevalence of confirmed alcoholic liver disease (ALD), suspected ALD and nonalcoholic fatty liver disease (NAFLD) was 1.1%, 2.1%, and 20.4%, respectively. The overall prevalence of FLD increased with age in both genders to the peak of 30.4% in 50~60 year group. Multivariate regression logistic regression analysis indicated that male gender, low education, high blood pressure, body mass index, waist circumference, waist hip ratio, serum triglyceride levels and glucose levels were risk factors of FLD in Guangdong urban area.Conclusion FLD, especially NAFLD, is prevalent in Guangdong urban area. Many factors related to the metabolic syndrome are risk factors of FLD.