机体损伤反应综合征动物实验研究(多系统功能时空场变化探讨)

目的　旨在研究致病因素作用下机体损伤反应综合征的病理生理学规律。方法　实验 1,36犬随机分成六组 ,分别常温下阻断腹主动脉 0、15、2 5、35、4 5和 6 0min。通过获取血液动力学、血液生化、血气酸碱、血凝状态等指标 ,用以分析损伤后呼吸、酸碱水电解质、凝血、肝胰肾肠等系统之功能变化 ;实验 2 ,6犬获取心输出量、总外周阻力、右颈总与右股动脉血流等指标 ,用以分析损伤后心血管系统血液动力学之功能变化 ;实验 3,从实验各组取 3犬获取肝肾胰肠组织 ,另取 18犬随机分 6组获取脑 ,脊髓组织 ,用以分析损伤后神经、呼吸、肝胰肾之结构变化 ;实验 4 ,30犬随机分成 5组 ,分别阻断或不阻断主动脉或给药物或蛇毒 ,通过获取膈神经与膈肌电位变化 ,用以分析损伤后神经系统之一功能变化 ;实验 5 ,6犬同步监测脑电图 ,心电图与呼吸电图变化 ,用以分析损伤后神经系统等功能学变化。结果　常温下腹主动脉阻断方法能导致机体损伤反应综合征 ;本实验方法也是一种机体损伤反应综合征的动力实验模型。结论　机体损伤反应综合征是一种多系统时空理论 ,对精典病理生理学理论体系重新认识 ,也是一种针对时空论理论 ,临床大部分疾病或综合征之生命时空场的“大统一”观点

The prospective experimental study on body injury response syndrome (I. Investigation of the time-space-field changes of multisystem functions) --Revaluation on the contemporary pathophysiology by applying multisystem time-space theory

Objective This study is to investigate the regulations of the functional changes of body injury response syndrome (BIRS) under the influence of the pathogenesis.Methods (1) In the experiment I, 36 healthy dogs were randomly divided into 6 groups and abdominal aortas of each group had been clamped respectively for 0, 15, 25, 35, 45 and 60minutes; the data of hemodynamics, blood acid|base and plasma electrolytes, coagulation state were collected and analyzed for the functions changes of multisystems after injury. (2)In the experiment II, cardiac output, total peripheral resistance, right carotid and femoral arterial flow of 6 dogs were measured for analysis of the functional changes of hemodynamics of the circulation systems. (3) In the experiment III, the tissues of kidney, liver, pancreas and intestine from 3 dogs in each group of the experiment I and tissues of brain, spinal and lung from other 18 dogs (also divided into 6 groups) were obtained and analyzed for the structural changes of multisystems after injury by electronic microscopy. (4) In the experiment IV, 30 healthy dogs were randomly divided into 5 groups which were with or without abdominal aorta clamping or with pharmaceutical or snake venom stimuli, the functional{ }changes of the central or peripheral nerve system after injury were analyzed by measuring action potential of diaphragmatic nerve and muscle synchronously. (5) In the experiment V, the functional changes of EEG, ECG and action potential of respiration were measured synchronously for analysis of the functional changes of central nerve system. Results The method of the abdominal aorta clamping could lead to body injury response syndrome (BIRS) and this experimental method was in fact the experimental model of BIRS.Conclusion BIRS is a kind of multisystem time|space theory (also called "general life time|space|field theory") and reevaluates the contemporary pathophysiology and is a great unified view for the changes of pahtophysiologic process in the total diseases and syndromes.