| ERK1蛋白在结直肠癌组织中的表达及临床意义 |
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| 引用本文： | 苏连明,朱雯,王程程.ERK1蛋白在结直肠癌组织中的表达及临床意义[J].牡丹江医学院学报,2010,31(1):11-13. |
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| 作者姓名： | 苏连明 朱雯 王程程 |
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| 作者单位： | 1. 牡丹江医学院附属红旗医院,黑龙江,牡丹江,157011
2. 牡丹江市爱民区疾病预防控制中心,黑龙江,牡丹江,157011 |
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| 摘 要： | 目的：探讨结直肠癌组织中ERK1的表达。方法：用免疫组化快捷法检测检测40例结直肠癌组织、18例结直肠腺瘤、13例结直肠正常黏膜组织中ERK1的表达,并分析与临床病理特征,侵袭性的关系。结果：结直肠癌组织ERK1蛋白表达的阳性率（70.0%）明显高于正常结直肠黏膜组（23.1%）及腺瘤组（61.1%）,组间比较差异有显著性（P〈0.05）,其表达随结直肠癌侵润深度增加、淋巴结转移、Duke分期的进展而增高。结论：ERK1的表达一定程度上反映结直肠癌侵袭性强弱。
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| 关 键 词： | ERK1 结直肠癌 蛋白表达 免疫组化 |
EXPRESSION AND SIGNIFICANCE OF ERK1 IN COLORECTAL CANCER |
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| Su Lianming et al.EXPRESSION AND SIGNIFICANCE OF ERK1 IN COLORECTAL CANCER[J].Journal of Mudanjiang Medical College,2010,31(1):11-13. |
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| Authors: | Su Lianming |
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| Institution: | Hongqi Hospital Attached to Mudanjiang Medical College Mudanjiang Heilongjiang 157011 |
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| Abstract: | Objective：To explore the expressions of ERK1of its malignant behaviors in colorectal cancer.Methods：By using kuaijie method,the expression of ERK1 in 40 cases of colorectal cancer 、18 cases of colorectal adenomas、13 cases of normal colorectal tissues.Results：The positive rate of ERK1 was higher in colorectal cancer（70.0%）than that in colorectal adenomas（61.1%）and normal tissues（23.1%）（p0.05）,and with the development of tissue invasiveness,lymphnode metastasis and Dukes stage,expression level of ERK1 become more higher.Conclusion The expression of ERK1 may reflect the differentiation and invasive potential of colorectal cancer tissues to varying degrees. |
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| Keywords: | ERK1 colorectal cancer expression of protein immunohistochemistry |
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