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MMP9和CD147在乳腺癌的表达及意义
引用本文:侯志斌,郭新建.MMP9和CD147在乳腺癌的表达及意义[J].青海医药杂志,2008,38(3):9-11.
作者姓名:侯志斌  郭新建
作者单位:1. 青海省西宁市第二人民医院病理科,810003
2. 青海大学医学院附属医院病理科,810001
摘    要:目的:探讨基质金属蛋白酶-9(MMP9)和CD147在乳腺癌中的表达及意义。方法:应用免疫组化染色S-P法,检测88例乳腺癌组织石蜡切片中MMP9及CD147的表达情况。结果:乳腺癌患者MMP9的表达与肿瘤的分级、大小无明显关系,与淋巴转移有明确相关联系(P<0.05)。CD147与病理分级、淋巴结转移的表达呈显著性正相关(P<0.05)。结论:CD147和MMP9相互影响参与了乳腺癌的侵袭与转移,两种物质的检测是判断乳腺癌预后与治疗的重要指标之一。

关 键 词:基质金属蛋白酶-9(MMP9)  CD147  乳腺癌  免疫组化

The Expression and Its Significances of MMP9 and CD147 Protein in Breast Cancer
Hou Zhibin,Guo Xinjian.The Expression and Its Significances of MMP9 and CD147 Protein in Breast Cancer[J].Qinghai Medical Journal,2008,38(3):9-11.
Authors:Hou Zhibin  Guo Xinjian
Institution:Hou Zhibin1; Guo Xinjian21 The 2nd People’s Hospital of Xining City2 Affiliated Hospital of Qinghai University;
Abstract:Objective:To observe the expression and its significances of MMP9 and CD147 protein in breast cancer. Methods:Expression of MMP9 and CD147 protein in 88 patients with breast cancer was measured by immunohistochemistry (S-P) method. Results:Expression of MMP9 protein positively correlate with lymph node metastasis (P<0.05) but there was no relation to tumor grades and tumor size (P>0.05).The correlation existed between expression of CD147 protein and tumor grades and lymph node metastasis (P<0.05).C...
Keywords:Breast cancer  CD147  MMP9  Immunohistochemistry
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